Fluorinated Alcohol Mediated N,N ’-Dialkylation of Amino Acids via Cascade [1,5]-Hydride Transfer/Cyclization for Concise Synthesis of Tetrahydroquinazoline

Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02498K, PaperHongjin Shi, Lubin Xu, Didi Ren, Liang Wang, Weisi Guo, Shuai-Shuai Li Structurally diverse amino acids and their ester derivatives were conveniently N,N ’-dialkylated via a TFE-promoted cascade condensation/[1,5]-hydride transfer/cyclization for straightforward construction of pharmeutically significant tetrahydroquinazolines incorporating various amino acids, which featured... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research