Sex differences in the hypothalamic-pituitary-adrenal axis response following a single or multiple days of sleep restriction.

Sex differences in the hypothalamic-pituitary-adrenal axis response following a single or multiple days of sleep restriction. Stress. 2019 Dec 30;:1-28 Authors: Buban KN, Shupe EA, Rothwell SW, John Wu T Abstract One in three adults report experiencing inadequate or disrupted sleep throughout the night, with the incidence being higher in women than in men. Disturbances in nightly sleep results in physiological alterations that contribute to a number of disorders. Poor sleep quality is believed to contribute to the pathogenesis of these disorders through interactions with the hypothalamic-pituitary-adrenal (HPA) axis. The present study investigated the effect of one and three days of restricted sleep on HPA axis reactivity. Male and female C57BL/6J (n = 8/group) mice were sleep-deprived for a 20h period for one day or three consecutive days using the modified multiple platform method, and then subjected to acute restraint stress. In response to sleep restriction, males showed blunted restraint-induced rises in CORT relative to controls. After three days of restricted sleep, females showed a similar attenuation in restraint-induced CORT. However, this effect was ablated after a single day of sleep restriction. Analyses of gene expression revealed significant elevations in the expression of pituitary HPA axis regulatory genes proopiomelanocortin and corticotropin releasing factor receptor 1 in both sexes following sleep restriction....
Source: Stress - Category: Research Tags: Stress Source Type: research