Endosomal dysfunction impacts extracellular vesicle release: central role in A β pathology.
Endosomal dysfunction impacts extracellular vesicle release: central role in Aβ pathology. Ageing Res Rev. 2019 Dec 28;:101006 Authors: Arbo BD, Cechinel LR, Palazzo RP, Siqueira IR Abstract Alzheimer's Disease (AD) is characterized by progressive loss of cognitive abilities; senile plaques represent the major histopathological findings. Amyloid precursor protein (APP) processing machinery, and its product amyloid-beta (Aβ) peptide, have been found in extracellular vesicles (EVs), specifically exosomes, which allows for Aβ peptide aggregation and subsequent senile plaques deposition. We review the APP processing imbalance in EVs, autophagic and endosomal pathways in AD. Increased intraluminal vesicle (ILV) production and exosome release appear to counteract the endosomal dysfunction of APP processing; however, this process results in elevated amyloidogenic processing of APP and augmented senile plaque deposition. Several players related to APP processing and dysfunctional endosomal-lysosomal-exosomal (and other EVs) pathway are described, and the interconnected systems are discussed. The components Arc, p75, Rab11 and retromer complex emerge as candidates for key convergent mechanisms that lead to increased EVs loaded with APP machinery and Aβ levels, in atrophy and damage of basal forebrain cholinergic neurons in AD. PMID: 31891813 [PubMed - as supplied by publisher]
Analyst, 2020, Accepted Manuscript DOI: 10.1039/D0AN00924E, PaperYong-Ill Lee, Qi Ou, Salah Mahmoud Tawfik, xinfeng Zhang An increasing number of patients are living with Alzheimer's disease (AD); thus, the need for a method to detect AD early and sensitively has become urgent, and the demand for... The content of this RSS Feed (c) The Royal Society of Chemistry
Analyst, 2020, Advance Article DOI: 10.1039/D0AN00440E, PaperXing Ze Wang, Jing Du, Nan Nan Xiao, Yan Zhang, Ling Fei, Jed D. LaCoste, Zhuo Huang, Qian Wang, Xin Rui Wang, Bin Ding ThT@Er-MOF has been successfully applied in highly sensitive detection of three main Alzheimer Disease biomarkers through three different low cost and facile detection strategies. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Conditions: Alzheimer Disease; Dementia Interventions: Device: tDCS device model Soterix mini-CT (Soterix Medical Inc., New York, NY) programed to deliver active tDCS.; Device: tDCS device model Soterix mini-CT (Soterix Medical Inc., New York, NY) programed to deliver sham tDCS. Sponsors: Albert Einstein College of Medicine; MJHS Institute for Innovation in Palliative Care Not yet recruiting
This study aimed to investigate the neural correlates of hippocampal downregulation associated with core Alzheimer's disease CSF biomarkers.Brain
An experimental tau inhibitor in development for Alzheimer's also has significant pharmacologic activity in bvFTD, a rare, rapidly progressive type of dementia that affects those younger than 65.Medscape Medical News
ConclusionsThe results demonstrate that even subtle changes in vessel morphology can be noninvasively quantified. This is of great interest for AD, but also to other models of neurodegenerative diseases involving macrovascular dysfunction.
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00278
In this study, our previously proposed persistent features and various traditional graph-theoretical measures are used to quantify the topological property of white matter (WM) network in 150 subjects with diffusion tensor imaging (DTI). We found significant differences in these measures among AD, MCI, and normal controls (NC) under different brain parcellation schemes. The decreased network integration and increased network segregation are presented in AD and MCI. Moreover, the persistent homology-based measures demonstrated stronger statistical capability and robustness than traditional graph-theoretic measures, suggesti...
Alzheimer's disease (AD) has an estimated prevalence of 50 million persons worldwide1 and an incidence of 10 million cases per year1-3, making it the most common form of dementia. While neuropsychiatric symptoms (NPS) are common in AD, apathy is particularly frequent, affecting up to 70% of patients4. Apathy has been broadly defined as a loss of interest in daily activities and diminished goal directed behavior in the absence of depression and other mood changes5 –7 . This NPS is associated with greater functional impairment, greater caregiver burden, increased risk of institutionalization, poorer quality of life, an...
ConclusionsMultiple signal pathways involve therapeutic mechanisms by which the transplantation of BMMSCs improves cognitive and behavioral deficits in AD models. Gene expression profile can be utilized to establish statistical regression model for the evaluation of therapeutic effect. The transplantation of autologous BMMSCs maybe a prospective therapy for patients with Alzheimer ’s disease.