Update on pediatric hyperthyroidism

Purpose of review This review is intended to highlight recent studies which provide new data on the epidemiology and management of children with hyperthyroidism, including neonates. Recent findings A French study demonstrates differences in age-related trends in incidence of hyperthyroidism in males versus females and suggests the overall incidence may be increasing. New studies confirm the effectiveness and safety of long-term medical therapy (up to 10 years), including from the first randomized trial of short-term versus long-term therapy. Radioiodine ablation (RAI) is the main alternative therapy, though surgery may have some advantages if done in a high-volume center; using higher weight-based doses of I-131 (250 μCI/g thyroid tissue) could increase proportion of patients achieving hypothyroidism and decrease repeat ablations. Maternal or neonatal thyroid-stimulating hormone (TSH) receptor antibodies in children of mothers with Graves’ disease, and TSH at 3–7 days of age are good predictors of which neonates will have problems. Summary More research is needed on the epidemiology of Graves’ disease. Long-term medical therapy well past two years should be considered an option in compliant patients to decrease the number who need definitive therapy. For those receiving RAI, a dose of about 250 μCI/g thyroid tissue should result in fewer cases of persistent hyperthyroidism than lower doses.
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: GROWTH AND DEVELOPMENT: Lynne L. Levitsky Source Type: research

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Jie Cai1†, Yi Zhang1†, Yuying Wang1, Shengxian Li1, Lihua Wang1, Jun Zheng1, Yihong Jiang1, Ying Dong1, Huan Zhou1, Yaomin Hu1, Jing Ma1, Wei Liu1,2*† and Tao Tao1*† 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Pudong, China 2Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Pudong, China Background: Infertility and dyslipidemia are frequently present in both women...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Discussion: T3 dilates peripheral arterioles and decreases systemic vascular resistance which stimulates renin secretion and increases effective arterial blood volume. Also, it increases heart rate and cardiac contractility. These mechanisms lead to increase in blood pressure. On the other hand, the mechanism with hypothyroidism is not fully recognized. It is thought to be secondary to increase in systemic vascular resistance. Through our study, we can conclude that the risk of hypertension is greater in patients with hyperthyroidism than with hypothyroidism.
Source: Hypertension - Category: Cardiology Authors: Tags: Poster Abstract Presentations Source Type: research
Publication date: Available online 10 August 2017 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Mohamed Larbi Hamlaoui, Ammar Ayachi, Aoulia Dekaken, Adel Gouri Aims The aim of this study is to evaluate the prevalence of the metabolic syndrome and its compounds in subjects with different thyroid status. Materials and methods A prospective cross-sectional study was conducted in the internal medicine department at El Okbi Hospital of Guelma (East of Algeria) from January 2014 to September 2015. Eighty six patients attending the specialist consultation for suspected thyroid disorders we...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
CONCLUSION: Findings from the current study suggest an increasing frequency of secondary forms of hypertension, highlighting the burden of OSA and PA in hypertensive patients. PMID: 28691036 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Discussion Fatigue is a subjective feeling of decreased energy, tiredness or feeling of exhaustion. Lethargy is often used synonymously, but lethargy is a state of being drowsiness or sleepy, and implies mental status changes. Both can cause the person to be apathetic or less active. Fatigue is a common state that almost everyone experiences multiple times in his or her lifetime. For most people it is a relatively acute or short-term chronic problem, often with a relatively easily identifiable problem cause, such as inadequate sleep, acute illness, or overexertion. For some, it can be less readily identifiable such as dep...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Which of the following is not a cause for elevated LDL cholesterol ? a) Pregnancy b) Hyperthyroidism c) Uncontrolled diabetes mellitus d) Obesity Correct answer: b) Hyperthyroidism Hypothyroidism is associated with elevated LDL cholesterol and triglycerides. Cholesterol and triglycerides rise progressively through out pregnancy. It may be noted that treatment with statins, niacin and ezetimibe are contraindicated in pregnancy and lactation. Triglycerides are elevated in poorly controlled diabetes mellitus. Both triglycerides and cholesterol are elevated in obesity [1]. Reference 1. Stone NJ et al. 2013 ACC/AHA guidel...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Authors: Lapa C, Maya Y, Wagner M, Arias-Loza P, Werner RA, Herrmann K, Higuchi T Abstract BACKGROUND: Brown adipose tissue (BAT) attracts growing interest as a potential therapeutic target for obesity and diabetes. Hyperthyroidism is well-known to increase BAT activity, but the role of hypothyroidism is controversial. We aimed to investigate the association between different thyroid hormone (TH) states and BAT activity. METHODS: FDG-PET studies were retrospectively evaluated in thyroid cancer patients after total thyroidectomy both at euthyroidism during TH replacement or at hypothyroidism after TH cessation. ...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
Purpose The development of endocrinopathies in survivors of childhood cancer as they age remains understudied. We characterized endocrine outcomes in aging survivors from the Childhood Cancer Survivor Study on the basis of therapeutic exposures. Patients and Methods We analyzed self-reported conditions in 14,290 5-year survivors from the Childhood Cancer Survivor Study, with a median age 6 years (range,
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Long Term Survival & Late Effects, Rapid Communications, Rapid Communications Source Type: research
ConclusionThis cohort study of elderly persons in Taipei City found a significant association between hypothyroidism and development of CKD in women and individuals without DM.
Source: Journal of the American Geriatrics Society - Category: Geriatrics Authors: Tags: Clinical Investigations Source Type: research
Authors: Lapa C, Maya Y, Wagner M, Arias-Loza P, Werner RA, Herrmann K, Higuchi T Abstract Background Brown adipose tissue (BAT) attracts growing interest as a potential therapeutic target for obesity and diabetes. Hyperthyroidism is well-known to increase BAT activity, but the role of hypothyroidism is controversial. We aimed to investigate the association between different thyroid hormone (TH) states and BAT activity. Methods FDG-PET studies were retrospectively evaluated in thyroid cancer patients after total thyroidectomy both at euthyroidism during TH replacement or at hypothyroidism after TH cessation. Serum ...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
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