Sexual dimorphism in the microbiology of the CF ‘Gender Gap’: Estrogen modulation of Pseudomonas aeruginosa virulence

In conclusion, we have demonstrated for the first time that estrogen exacerbates P. aeruginosa virulence factors and enhances bacterial interactions with CF bronchial epithelium which can be inhibited by tamoxifen. Our work suggests that SERMs could be used as an adjuvant treatment to block estrogen-induced P. aeruginosa infections and associated lung exacerbations in females with CF.Graphical abstract
Source: Steroids - Category: Drugs & Pharmacology Source Type: research