Recombination-induced revertant mosaicism in ichthyosis with confetti and loricrin keratoderma

The average human body is estimated to comprise 37.2 trillion cells [1], and during the transformation from a single fertilized egg into an adult human, each cell inevitably accumulates numerous genetic and/or genomic alterations by multiple factors, including intrinsic DNA replication errors and environmental DNA insults [2,3]. In principle, these alterations can occur at any time point after the first zygotic division [3]. Therefore, mosaicism, the occurrence of more than one genetically diverse cell population in an organism arising from a single fertilized egg, is a natural condition —rather than exception—of all somatic tissues, including the skin.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Tags: Invited Review Article Source Type: research