A phase II trial of single oral FGF inhibitor, AZD4547, as second or third line therapy in malignant pleural mesothelioma

Systemic chemotherapy remains the mainstay of treatment for patients with unresectable malignant pleural mesothelioma (MPM). In 2003, the EMPHACIS trial established cisplatin and pemetrexed as the standard of care for first-line treatment of advanced mesothelioma [1]. More recently, the MAPS trial provided the first randomised demonstration of efficacy of a targeted therapy in mesothelioma, with the addition of bevacizumab to cisplatin and pemetrexed chemotherapy providing a small incremental survival benefit over chemotherapy alone, increasing median survival from16.1 to 18.8 months [2].
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research

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Authors: Sano M, Kaneko MK, Kato Y Abstract The highly O-glycosylated membrane glycoprotein podoplanin (PDPN) is frequently overexpressed in several malignant cancers, such as oral cancer, lung cancer, germinal neoplasia, mesothelioma, and brain tumor. The expression of PDPN is strongly associated with cancer progression and poor prognosis. PDPN possesses three tandem repeats of platelet aggregation-stimulating (PLAG) domains (PLAG1, PLAG2, and PLAG3) and PLAG-like domain (PLD), and binds to C-type lectin-like receptor 2 (CLEC-2) on platelets, followed by PDPN-mediated platelet aggregation. We have previously estab...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
This study aimed to explore whether a correlation exists between the incidence and mortality of cancers and normalized internet search volumes on the big data platform, Baidu. We also assessed whether the distribution of people who searched for specific types of cancer differed by gender. Finally, we determined whether there were regional disparities among people who searched the Web for cancer-related information. Methods: Standard Boolean operators were used to choose search terms for each type of cancer. Spearman’s correlation analysis was used to explore correlations among monthly search index values for each can...
Source: Journal of Medical Internet Research - Category: General Medicine Authors: Source Type: research
This study supports the use of intravenous dexamethasone 10 mg before pemetrexed infusion in place of three days of oral dexamethasone 4 mg twice daily at UNMCCC,” the authors wrote. The post Alimta-Related Skin Reactions with and Without Oral Steroids appeared first on Mesothelioma Center - Vital Services for Cancer Patients &Families.
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
A recent report from the Environmental Protection Agency’s internal watchdog shows the agency isn’t doing enough to minimize asbestos risks in U.S. schools. From 2011 through 2015, the EPA conducted only 13 percent of the Asbestos Hazard Emergency Response Act (AHERA) inspections it was responsible for nationwide, according to a report released Monday by the EPA’s Office of Inspector General. States with jurisdiction over their own inspections performed 87 percent, more than six times that of federal implementation jurisdictions. “Our objective was to determine whether the EPA was performing suffici...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
In this study, a series of deletion or point mutants of cPDPN were utilized for investigating the binding epitopes of PMab-52 using flow cytometry and Western blotting. The findings of this study revealed that the critical epitopes of platelet aggregation-stimulating domain 4 (PLAG4) of cPDPN are responsible for the binding of PMab-52 to cPDPN. PMID: 29394131 [PubMed - as supplied by publisher]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
In this study, we investigated podoplanin expression in 40 feline squamous cell carcinomas (14 cases of mouth floor, 13 of skin, 9 of ear, and 4 of tongue) by immunohistochemical analysis using an anti-cat podoplanin mAb PMab-52, which we recently developed by cell-based immunization and screening (CBIS) method. Of the total 40 cases, 38 (95%) showed positive staining for PMab-52. In particular, 12 cases (30%) showed a strong membrane-staining pattern of squamous cell carcinoma cells. PMab-52 can be useful for antibody therapy against feline podoplanin-expressing squamous cell carcinomas. PMID: 29090969 [PubMed - as supplied by publisher]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
This study demonstrates the feasibility of this approach since both preliminary encouraging signs of activity and no unexpected toxicities were observed, in this heavily pre-treated patients’ population.” Study Size and Rarity of Mesothelioma Present Challenges As a phase I clinical trial, it is a novel approach at this point but a promising step for future chemotherapy treatment plan protocols. The limited number of patients in the study — nine NSCLC and three mesothelioma — is also problematic, but the planned second phase of the study will include the new model’s effect on the immune syste...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Aix-Marseille University anemia chemotherapy best vinorelbine regimen chemotherapy side effects Fabrice Barlesi low-dose oral chemotherapy drugs math cancer chemotherapy math to fight cancer mathematical modeling cancer mesothelioma chem Source Type: news
CONCLUSIONS: Responses with acceptable safety profile were observed in heavily pretreated NSCLC and mesothelioma patients using oral vinorelbine at this metronomic dosage based on a mathematic modeling. This study demonstrates the feasibility of this new type of approach, as mathematical modeling may help to rationally decide the better regimen to be clinically tested across infinite possibilities. PMID: 28525370 [PubMed - as supplied by publisher]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Thoracoscopy is a procedure used to examine the pleural space for diagnostic and therapeutic purposes. It is a percutaneous procedure performed under general anesthesia that requires hospitalization. Several small incisions are made and the surgeon inserts a thin scope through one of them into the pleural space. When the procedure is finished, a tube is temporarily placed to drain fluid and air. The major diagnostic indication is a pleural effusion of unknown etiology (20% of cases). It has a high sensitivity for the diagnosis of malignant diseases like mesothelioma or lung cancer, and changes the clinical management of th...
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstract Source Type: research
This study provides evidence that some patients [with mesothelioma] can have long-term disease control with this drug, which we haven’t seen before,” Alley said in a press release. “This drug appears to be well tolerated.” Real Need for Second-Line Therapy Standard first-line therapy for mesothelioma includes a combination of chemotherapy, radiation and surgery, but it remains relatively ineffective as a long-term solution. Alley believes pembrolizumab, classified as a checkpoint inhibitor drug, can provide a needed advancement in treatment. Checkpoint inhibitors allow the immune system to fight off...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Abramson Cancer Center checkpoint inhibitors Dr. Evan Alley keytruda keytruda clinical trials keytruda for mesothelioma Merck & Co. PD-L1 proteins pembrolizumab Pembrolizumab mesothelioma Penn Medicine Penn Presbyterian Medical Cente Source Type: news
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