Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP

This study focuses on Rab2 and Rab3 from Drosophila melanogaster. Whereas Rab2 is involved in vesicle transport between the Golgi and the endoplasmatic reticulum, Rab3 is a key player in exocytosis, and in the synapse it is involved in the assembly of the presynaptic active zone. Here, high-resolution crystal structures of Rab2 and Rab3 in complex with GMPPNP and Mg2+ are presented. In the structure of Rab3 a modified cysteine residue is observed with an enigmatic electron density attached to its thiol function.

Source: Acta Crystallographica Section F - December 24, 2014 Category: Biochemistry Authors: Lardong, J.A.Driller, J.H.Depner, H.Weise, C.Petzoldt, A.Wahl, M.C.Sigrist, S.J.Loll, B. Tags: Rab GTPase GMPPNP cysteine modification research communications Source Type: research