Divergent effects of canonical and non-canonical TGF- β signalling on mixed contractile-synthetic smooth muscle cell phenotype in human Marfan syndrome aortic root aneurysms.

In conclusion, in human MFS aortic SMCs: (a) ERK activation is enhanced but not specific to the site of aneurysm formation; (b) ERK opposes TGF-β-dependent negative effects on SMC phenotype; (c) multiple distinct SMC subtypes contribute to a 'mixed' contractile-synthetic phenotype in MFS aortic aneurysm; and (d) ERK drives Notch3 overexpression, a potential pathway for tissue remodelling in response to aneurysm formation. PMID: 31886938 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31886938?dopt=Abstract

Source: J Cell Mol Med - December 29, 2019 Category: Molecular Biology Authors: Pedroza AJ, Koyano T, Trojan J, Rubin A, Palmon I, Jaatinen K, Burdon G, Chang P, Tashima Y, Cui JZ, Berry G, Iosef C, Fischbein MP Tags: J Cell Mol Med Source Type: research