92: A novel epigenetic mechanism underlying maternal diabetes-suppressed mitochondrial fusion in congenital heart disease

Maternal diabetes, induces congenital heart defects (CHDs), the most common structural birth defects in human. microRNAs (miRNA) are non-coding RNAs, which represses gene expression by degrading mRNA and/or inhibiting translation. Previous studies indicate that miRNAs are potentially involved in the pathogenesis of heart defects in diabetic pregnancy. The present study investigates the role of miR-140 in maternal diabetics-induced CHDs by examining its impact on mitochondrial dynamics.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Oral Concurrent 8 Source Type: research