93: Tissue graft materials for skin patch during in-utero spina bifida repair in a sheep model

Use of off-label tissue graft materials such as acellular dermal matrix (ADM) for the in-utero repair of severe spina bifida (SB), where primary closure of the skin layer is not possible, is associated with poor neurological outcomes. Cryopreserved human umbilical cord patch (HUC) has regenerative, anti-inflammatory and anti-scarring properties, and has shown to provide watertight SB repair. We tested the hypothesis that HUC is a superior skin patch compared to ADM for reducing inflammation at repair site and preserving the spinal cord function.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Oral Concurrent 9 Source Type: research