Successful planned pregnancy through vitrified-warmed embryo transfer in a woman with chronic myeloid leukemia: case report and literature review
A 35-year-old female patient with chronic myeloid leukemia wanted to have a child. She had been treated with imatinib and had achieved major molecular remission, after which imatinib was intentionally discontinued and interferon- α treatment was initiated. After three failed cycles of artificial insemination with her husband’s semen, the patient underwent treatment with assisted reproductive technology. After two cycles ofin vitro fertilization, two embryos (8-cell stage and blastocyst) were cryopreserved. The patient again had elevatedBCR/ABL mRNA levels; thus, infertility treatment was discontinued. After 18 months of dasatinib treatment, major molecular remission was observed and the patient underwent vitrified –warmed embryo transfer with a single blastocyst. Thereafter, she became pregnant. Discontinuation of tyrosine kinase inhibitors combined with the timely initiation of infertility treatments, including assisted reproductive technology, may be useful for treating women with CML who wish to become p regnant.
Authors: El-Demiry NM, Maged AM, Gaafar HM, ElAnwary S, Shaltout A, Ibrahim S, El-Didy HM, Elsherbini MM Abstract Objective: To evaluate the diagnostic performance of Doppler sonography of umbilical artery (UA), fetal middle cerebral artery (MCA), ductus venosus (DV) &umbilical vein (UV) for prediction of adverse perinatal outcome.Material and Methods: A prospective cohort study conducted on 60 women diagnosed with preeclampsia with severe features divided into two groups based on adverse perinatal outcome.Results: Statistically Significant differences were demonstrated UA PI (1.28 ± 0.23 vs. 0.96 ± 0.21, P
Publication date: Available online 25 February 2020Source: Journal of the Formosan Medical AssociationAuthor(s): Meng-Hsing Wu, Huang-Tz Ou
Publication date: March 2020Source: The Lancet Haematology, Volume 7, Issue 3Author(s): Motoharu Shibusawa
Publication date: March 2020Source: The Lancet Haematology, Volume 7, Issue 3Author(s): Stuart L Cohen, Chinara Feizullayeva, John A McCandlish, Pina C Sanelli, Thomas McGinn, Benjamin Brenner, Alex C Spyropoulos
Publication date: Available online 25 February 2020Source: Pharmacological ResearchAuthor(s): Robert Roskoski
Publication date: Available online 26 February 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Ben Ponvilawan, Nipith Charoenngam, Thanitsara Rittiphairoj, Patompong Ungprasert
Publication date: Available online 26 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Annalisa Biffi, Anna Cantarutti, Federico Rea, Anna Locatelli, Rinaldo Zanini, Giovanni Corrao
Publication date: July 2020Source: Food Control, Volume 113Author(s): Melissa Cater, Rebecca Gravois, Genesis G. Guerra Gaitan, Wenqing Xu
AbstractIn dairy cattle, the hormonal changes around calving induce large metabolic changes to support milk production. Mobilization of adipose reserves is one of the changes involved, imposing a metabolic load on the liver. We hypothesized that the risk for excessive lipolysis and hepatic lipidosis postpartum can be reduced by starting fat mobilization and processing during the prepartum period by physical exercise, especially in cows with a high body condition score (BCS). As a proof of concept, 32 pregnant Holstein ‐Friesian dairy cows were selected for a 2 × 2 experimental design. Sixteen cows had a BCS
Authors: Balayla J, Shrem G Abstract Every year, about 85 percent of the approximately 5 million births in North America are evaluated with the electronic fetal monitoring (EFM). Clinicians use the EFM as a proxy to assess fetal oxygenation status, fetal well-being, and potential compromise. Despite the widespread use of this technology, neonatal hypoxia and acidosis continue to make up a high proportion of neonatal morbidity at term. Indeed, though the fetal heart rhythm is inextricably linked to fetal acid-base status, EFM has not been shown to reliably predict neonatal pH status nor has it reduced adverse matern...