Mesothelial/monocytic incidental cardiac excrescence in autoimmune disease

AbstractMesothelial/monocytic incidental cardiac excrescence (MICE) is a rare benign finding made of mesothelial cells, histiocytes, and fibrin, usually found during heart valve surgery. The clinical relevance resides in the potential misdiagnosis as metastatic carcinoma or arterial embolism. The pathogenesis remains uncertain, with artifactual and reactive hypotheses. Here we present a case of MICE with paradigmatic clinical, imaging, and histological features in a 28 ‐year‐old woman with undifferentiated connective tissue disease without previous cardiac catheterization with possible pathogenesis, highlighting the importance of awareness of the existence of this lesion in patients with autoimmune disease.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research

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An 81 ‐year‐old man was admitted due to dyspnoea and haemoptysis. We suspected diffuse alveolar haemorrhage based on computed tomography (CT) findings of diffuse bilateral ground‐grass opacity and partial consolidation. Autopsy revealed pulmonary lymphangitic carcinomatosis of whole lungs and primar y gallbladder cancer. AbstractDiagnosis in cases with pulmonary lymphangitic carcinomatosis as a primary manifestation is difficult due to unawareness of the cancer. An 81 ‐year‐old man was admitted due to a one‐week history of dyspnoea and haemoptysis. Chest computed tomography showed diffuse bilateral ground‐gra...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
AbstractBackgroundAcute vasoreactivity testing (AVT) which reflects the compliance of the pulmonary vascular bed has been proven to be of prognostic value. The purpose of the present study is to explore the sex differences of hemodynamics during the AVT and their impact on event ‐free survival in patients with chronic thromboembolic pulmonary hypertension (CTEPH).MethodsEighty ‐six patients underwent a right heart catheterization and AVT at Shanghai Pulmonary Hospital from February 2009 to February 2018. Univariate and multiple stepwise regression analysis were performed to determine the predictors of independent event...
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: April 2020Source: Journal of Comparative Pathology, Volume 176Author(s): A. Rodríguez-Largo, R. de Miguel, J. Asín, F. Chocteau, M. Gimeno, P. Pinczowski, A. de Martino, L. Luján
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
Publication date: Available online 26 February 2020Source: Pathology - Research and PracticeAuthor(s): Yu Wang, Yingren Zhao, Xu Zhang, Aiyun Zhang, Juan Ma
Source: Pathology Research and Practice - Category: Pathology Source Type: research
No abstract available
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Surgeons' Corner Source Type: research
Abstract: Thyroid-associated ophthalmopathy (TAO) is an autoimmune component of Graves' disease for which no currently available medical therapy provides reliable and safe benefit. Based on insights generated experimentally over the past several decades, the insulin-like growth factor–I receptor (IGF-IR) has been implicated in the pathogenesis of TAO. Furthermore, an IGF-IR inhibitor, teprotumumab, has emerged from 2 clinical trials as a promising treatment for active, moderate to severe TAO. This brief review intends to provide an overview of the rationale underlying the development of teprotumumab for this diseas...
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Basic and Translational Research Source Type: research
CONCLUSIONS: Contrast-enhanced ultrasound might be safe and as accurate as histopathology in diagnosing kidney lesions, especially renal cell carcinoma. Additionally, this study provides additional information over histopathology and has an excellent safety profile. Level of evidence: III.
Source: Clinics - Category: General Medicine Source Type: research
Publication date: Available online 27 February 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Hongtu Wang, Bo Wang, Tao Wang, Ruixuan Fan
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Summary: Reconstruction of substantial-sized upper lip defects may require an Abbe flap reconstruction to avoid excessive tightness and deformity. The design of the Abbe or lip switch flap harvested from the lower lip is important for a satisfactory aesthetic and functional result. Harvest of the flap is performed to enable a definitive inset into the defect. The video that accompanies this article depicts rotation of an Abbe flap into a philtral defect created by basal cell carcinoma excision.
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: Reconstructive: Head and Neck: Video Source Type: research
AbstractAimsThe aim of this study was to investigate prospectively the effect of sacubitril/valsartan in advanced heart failure (HF) patients in waiting list for heart transplantation (HT) and the effect on physical frailty (PF).Methods and resultsWe treated 37 consecutive patients with advanced HF with sacubitril/valsartan. Patients were followed up until HT, device implant, or last follow ‐up visit after 2 years of follow‐up. At baseline, mean New York Heart Association (NYHA) class was 3.1 ± 0.4, with 64.9% in NYHA III and 35.1% NYHA IIIB. Left ventricular ejection fraction was 23.5 ± 5.8%, VO2 max was...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Short Communication Source Type: research
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