Complement activation in individuals with previous subclinical Lyme borreliosis and patients with previous Lyme neuroborreliosis
AbstractLyme borreliosis (LB) is caused byBorrelia burgdorferi and infection may lead to not only a large variety of clinical manifestations but also a subclinical outcome. The aim of the present study was to investigate if there is a constitutional difference in complement activation between individuals with previous subclinical Lyme borreliosis (SB) and patients previously diagnosed with Lyme neuroborreliosis (LNB).Lepirudin plasma for activation studies was collected from 60 SB individuals and from 22 patients pre-diagnosed with LNB. The plasma was incubated with liveBorrelia spirochetes of two strains (complement sensitiveB. garinii Lu59 and complement resistantB. afzelii ACA1).Complement factor C3 was measured in non-activated lepirudin plasma with immune-nephelometry and C3a and sC5b-9 generated during complement activation were measured by enzyme-linked immunosorbent assay.We found that the complement sensitive Lu59 induced higher complement activation than the complement resistant ACA1 when measuring activation products C3a and sC5b-9 in SB and LNB patients,p
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This article synthesizes the individual approaches of neurologists, psychiatrists, radiologists, infectious disease specialists, and psychologists when presented with the same case and the effective multidisciplinary integration of these efforts even when the exact diagnosis remains unknown. PMID: 32706944 [PubMed - in process]
M. Markowicz et al.
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