Spirostanol and sesquiterpenoid glycosides from the rhizomes of Trillium tschonoskii

Publication date: Available online 30 December 2019Source: SteroidsAuthor(s): Dan Li, Huan Yan, Jie Wang, Qian Yu, Wei Ni, Lin-Kun An, Xu-Jie Qin, Hai-Yang LiuAbstractThree new spirostanol glycosides, trilliumosides K–M (1–3), one new sesquiterpenoid glycoside, tritschsesuquiside A (4), along with three known analogues (5–7) were obtained from the rhizomes of Trillium tschonoskii. The structures of new glycosides were elucidated by spectroscopic analyses (HRMS and NMR) and chemical methods. Glycosides 5–7 displayed cytotoxicities against five human cancer cell lines with IC50 values ranging from 10.5 ± 1.0 to 1.0 ± 0.2 μM, with 7 being the most cytotoxic compound with IC50 values of 1.0 ± 0.2, 2.2 ±1.2, and 3.4 ± 0.4 μM against Huh7, CCRF-CEM, and HeLa cell lines, respectively. The flow cytometric results revealed that both 5 and 6 could induce apoptosis of HCT116 and Huh7 cells.Graphical abstract
Source: Steroids - Category: Drugs & Pharmacology Source Type: research