Acquired long QT syndrome in chronic kidney disease patients.
Acquired long QT syndrome in chronic kidney disease patients. Ren Fail. 2020 Nov;42(1):54-65 Authors: Liu P, Wang L, Han D, Sun C, Xue X, Li G Abstract Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP), sudden cardiac death (SCD), and all-cause mortality in the general population. The prevalence of acquired long QT syndrome (aLQTS) is high, and various acquired conditions contribute to the prolonged QT interval in patients with CKD. More notably, the prolonged QT interval in CKD is an independent risk factor for SCD and all-cause mortality. In this review, we focus on the epidemiological characteristics, risk factors, underlying mechanisms and treatments of aLQTS in CKD, promoting the management of aLQTS in CKD patients. PMID: 31878817 [PubMed - in process]
ConclusionsPatients with CMS were more likely to present with increased comorbidities. Patients with CMS undergoing CABG were at risk for worse short ‐term secondary postoperative outcomes and reduced long‐term survival. The data supports the need for further investigation for risk reduction surrounding operative revascularization.
AbstractIn a rapidly expanding population of patients with chronic kidney disease, including 2 million people requiring renal replacement therapy, cardiovascular mortality is 15 times greater than the general population. In addition to traditional cardiovascular risk factors, more poorly defined risks related to uraemia and it ’s treatments appear to contribute to this exaggerated risk. In this context, the microcirculation may play an important early role in cardiovascular disease associated with chronic kidney disease. Experimentally the uraemic environment and dialysis have been linked to multiple pathways causing...
This report describes a case of hantavirus-associated acute renal failure and proteinuria. How was this case ultimately diagnosed?Emerging Infectious Diseases
Conclusions: Leukopenia could be an objective prognostic factor for left colonic perforation. Although HP is the gold standard for septic left colonic perforation, it did not improve overall mortality of the patients without leukopenia. For such patients, PR or PA could be a good option for left colonic perforation. PMID: 32054246 [PubMed - as supplied by publisher]
Conclusion: We proposed that the crescents were not uncommon and had important clinical significance in lupus nephritis. The cutoff point of crescents as prognosticator might be nearly 7.39%. PMID: 32054387 [PubMed - in process]
Type 2 diabetes mellitus (T2DM) is a considerable risk factor of cardiovascular disease, heart failure, chronic kidney disease, and mortality [1 –4]. Diabetes caused 4 million deaths in 2017, with more than 0.84 million in China . The prevalence of T2DM is increasing in many countries with the speeding up of urbanization and change in lifestyle. The International Diabetes Federation estimated that approximately 425 million adults (20– 79 years) were living with diabetes in 2017, 79% were from low- and middle-income countries, and this number would rise to 629 million by 2045 .
Publication date: March 2020Source: Molecular Genetics and Metabolism Reports, Volume 22Author(s): Olga Azevedo, Miguel F. Gago, Gabriel Miltenberger-Miltenyi, Ana Raquel Robles, Maria Antónia Costa, Olga Pereira, Ana Teresa Vide, Gonçalo Castelo Branco, Sónia Simões, Maria José Guimarães, Ana Salgado, Nuno Sousa, Damião CunhaAbstractBackgroundThe common GLA gene mutation p.F113L causes late-onset phenotype of Fabry disease (FD) with predominant cardiac manifestations. A founder effect of FD due to this mutation was found in the Portuguese region of Guimarães. Our stu...
Conclusions: Our study suggests that elevated serum PAPP-A is associated with the risk of all-cause mortality in patients with CKD. PMID: 32051700 [PubMed]
ConclusionsThe study demonstrated the worse prognostic value of sudden renal function decline in HF patients and pointed to those with more future risk who require review of treatment and closer follow ‐up.
AbstractBackgroundRenal hypoxia is considered a final pathway in the progression of chronic kidney disease (CKD). Blood-oxygen-level-dependent magnetic resonance imaging (BOLD-MRI) has shown merit for evaluating renal oxygenation in adults.ObjectiveTo investigate renal cortical and medullary R2* values by CKD stage and by renal function index in children with chronic kidney disease.Materials and methodsTwenty-one children with CKD Stage 1 –3, 16 children with CKD Stage 4–5, and 6 healthy volunteers underwent a renal MRI using multigradient recalled-echo sequence with 16 echoes. We measured the R2* values of the...