Epigenetic control of tumor angiogenesis

AbstractThe term “epigenetic” is used to refer to heritable alterations in chromatin that are not due to changes in DNA sequence. Different growth factors and vascular genes mediate the angiogenic process, which is regulated by epigenetic states of genes. The aim of this article is to analyze the role epigenetic mechanisms in the control and regulation of tumor angiogenetic processes. The reversibility of epigenetic events in contrast to genetic aberrations, makes them potentially suitable for therapeutic intervention. In this context, DNA methyltransferase (DNMT) and HDAC inhibitors indirectly – via the tumor cells – exhibit angiostatic effectsin vivo, and inhibition of miRNAs can contribute to the development of novel anti ‐angiogenesis therapies.

Source: Microcirculation - December 20, 2019 Category: Research Authors: Domenico Ribatti, Roberto Tamma Tags: REVIEW ARTICLE Source Type: research