Prior Gemtuzumab Ozogamicin Exposure in Adults With Acute Myeloid Leukemia Does Not Increase Hepatic Veno-occlusive Disease Risk After Allogeneic Hematopoietic Cell Transplantation: A CIBMTR Analysis

Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life-threatening complication that occurs primarily after hematopoietic cell transplantation (HCT) [1]. VOD/SOS is characterized by fluid retention, painful hepatomegaly, weight gain, and hyperbilirubinemia and results from injury to the sinusoidal endothelial cells due, at least in part, to the conditioning regimen [1,2]. The rate of VOD/SOS following HCT in historical cohorts ranges from 0 to 62.3%, with a mean of 13.7%, and is higher with allogeneic HCT (alloHCT) compared with autologous HCT [3].

Source: Biology of Blood and Marrow Transplantation - December 27, 2019 Category: Hematology Authors: Vincent T. Ho, Andrew St. Martin, Waleska S. P érez, Patricia Steinert, Mei-Jie Zhang, Deborah Chirnomas, Caroline J. Hoang, Fausto R. Loberiza, Wael Saber Source Type: research