Dawn of a New Era of Diabeto ‐Oncology

AbstractDiabetes mellitus and cancer have several risk factors in common (Figure 1). Besides these shared factors, they might directly trigger each other. Compelling evidence has been accumulated over the past decades that shows the increased risk of cancer in relation to diabetes in Western and Asian countries1. It is postulated that hyperglycemia and compensatory hyperinsulinemia in type 2 diabetes mellitus are the prevailing mechanisms through which diabetes directly raises cancer risk (Figure 1).
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: EDITORIAL Source Type: research

Related Links:

CONCLUSION: GDM is associated with a greater risk of cancer in women, including breast, thyroid, stomach and liver cancers. However, further investigation is nonetheless warranted. PMID: 32097717 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Tags: Diabetes Metab Source Type: research
Abstract Ketogenic diets have been proposed as a non-pharmacological strategy for the management of several chronic conditions. Their efficacy and safety have been evaluated in the field of neurology, oncology and endocrinology for disorders including cancer, dementia, drug-resistant epilepsy, migraines, obesity, polycystic ovary syndrome and type 2 diabetes mellitus. The nutritional requirements of these subjects are expected to differ significantly. Indeed, although all ketogenic diets restrict carbohydrates, each intervention is characterized by a specific daily calorie intake, macronutrient composition and dur...
Source: ENDOCR REV - Category: Endocrinology Authors: Tags: Rev Endocr Metab Disord Source Type: research
AbstractKetogenic diets have been proposed as a non-pharmacological strategy for the management of several chronic conditions. Their efficacy and safety have been evaluated in the field of neurology, oncology and endocrinology for disorders including cancer, dementia, drug-resistant epilepsy, migraines, obesity, polycystic ovary syndrome and type 2 diabetes mellitus. The nutritional requirements of these subjects are expected to differ significantly. Indeed, although all ketogenic diets restrict carbohydrates, each intervention is characterized by a specific daily calorie intake, macronutrient composition and duration. How...
Source: Reviews in Endocrine and Metabolic Disorders - Category: Endocrinology Source Type: research
Abstract Metformin is one of the most commonly used first-line oral medications for type 2 diabetes mellitus. Multiple observational studies, reviewed in numerous systematic reviews, have shown that metformin treatment may not only reduce the risk of cancer but may also improve the efficacy of cancer treatment in diabetic patients. Recent studies have been conducted to determine whether a similar protective effect can be demonstrated in nondiabetic cancer patients. However, the results are controversial. The potential optimal dose, schedule, and duration of metformin treatment and the heterogeneity of histological...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Publication date: Available online 5 February 2020Source: Trends in Pharmacological SciencesAuthor(s): Fabrizio Marcucci, Elisabetta Romeo, Carmelo A. Caserta, Cristiano Rumio, François LefoulonMetformin is used for the treatment of type 2 diabetes mellitus and has shown therapeutic effects in preclinical models of other pathologies, such as cancer and autoimmune diseases. The antitumor activity of metformin is due, in part, to immunostimulatory effects. In the context of other pathologies, such as autoimmune or inflammatory diseases, metformin has immunosuppressive effects. There is evidence that the immunostimulat...
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: Breakfast consumption
Source: The American Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Am J Clin Nutr Source Type: research
As primary care physicians, advance practice providers, or other members of the health care team, we recommend physical activity to most if not all patients we see. On a population basis, and most importantly, regular physical activity prevents the development of coronary artery disease and reduces symptoms in patients with established cardiovascular disease. Furthermore, evidence supports the role of exercise in reducing the risk of several other chronic diseases, including type 2 diabetes mellitus, osteoporosis, obesity, and cancer of the breast and colon.
Source: Primary Care: Clinics in Office Practice - Category: Primary Care Authors: Tags: Preface Source Type: research
Authors: Liu J, Yang L Abstract Effects of propofol and sevoflurane on blood glucose, hemodynamics, and inflammatory factors of patients with type 2 diabetes mellitus (T2DM) and gastric cancer (GC) were investigated. One hundred and ten patients with T2DM and GC, treated in The First Affiliated Hospital of Baotou Medical College (Baotou, China) from January 2017 to December 2018, were selected. Sixty patients anesthetized by propofol were included in the propofol group, whereas 50 patients anesthetized by sevoflurane were included in the sevoflurane group. The level of blood glucose, hemodynamic indicators, and inf...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
sin Okada Yamada Dapagliflozin, empagliflozin, tofogliflozin, selective inhibitors of sodium-glucose cotransporter 2 (SGLT2), is used clinically to reduce circulation glucose levels in patients with type 2 diabetes mellitus by blocking the reabsorption of glucose by the kidneys. Dapagliflozin is metabolized and inactivated by UGT1A9. Empagliflozin is metabolized and inactivated by UGT1A9 and by other related isoforms UGT2B7, UGT1A3, and UGT1A8. Tofogliflozin is metabolized and inactivated by five different enzymes CYP2C18, CYP3A4, CYP3A5, CYP4A11, and CYP4F3. Dapagliflozin treatment of HCT116 cells, which express...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: Available online 22 January 2020Source: Journal of Advanced ResearchAuthor(s): Garima Bansal, Punniyakoti Veeraveedu Thanikachalam, Rahul K Maurya, Pooja Chawla, Srinivasan RamamurthyAbstractDiabetes or diabetes mellitus is a complex or polygenic disorder, which is characterized by increased levels of glucose (hyperglycemia) and deficiency in insulin secretion or resistance to insulin over an elongated period in the liver and peripheral tissues. Thiazolidine-2,4-dione (TZD) is a privileged scaffold and an outstanding heterocyclic moiety in the field of drug discovery, which provides various opportunities ...
Source: Journal of Advanced Research - Category: Research Source Type: research
More News: Cancer | Cancer & Oncology | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Endocrinology