Differential cortical and subcortical projection targets of subfields in the core region of mouse auditory cortex.

Differential cortical and subcortical projection targets of subfields in the core region of mouse auditory cortex.
Hear Res. 2019 Dec 24;386:107876
Authors: Nakata S, Takemoto M, Song WJ
Abstract
The core region of the rodent auditory cortex has two areas: the primary auditory area (A1) and the anterior auditory field (AAF). However, the functional difference between these areas is unclear. To elucidate this issue, here we studied the projections from A1 and AAF in mice using adeno-associated virus (AAV) vectors expressing either a green fluorescent protein or a red fluorescent protein. After mapping A1 and AAF using optical imaging, we injected a distinct AAV vector into each of the two fields at a frequency-matched high-frequency location. We found that A1 and AAF projected commonly to virtually all target areas examined, but each field had its own preference for projection targets. Frontal and parietal regions were the major cortical targets: in the frontal cortex, A1 and AAF showed dominant projections to the anterior cingulate cortex Cg1 and the secondary motor cortex (M2), respectively; in the parietal cortex, A1 and AAF exhibited dense projections to the medial secondary visual cortex and the posterior parietal cortex (PPC), respectively. Although M2 and PPC received considerable input from A1 as well, A1 innervated the medial part whereas AAF innervated the lateral part of these cortical regions. A1 also projected to the orbi...

Source: Hearing Research - December 23, 2019 Category: Audiology Authors: Nakata S, Takemoto M, Song WJ Tags: Hear Res Source Type: research