Impact of image preprocessing methods on reproducibility of radiomic features in multimodal magnetic resonance imaging in glioblastoma.

In this study, for each patient 1461 radiomics features were extracted from GBM subregions (i.e., edema, necrosis, enhancement, and tumor) of mMRI (i.e., FLAIR, T1, T1C, and T2) volumes for five preprocessing combinations (in total 116 880 radiomics features). The robustness and reproducibility of the radiomics features were assessed under four comparisons: (a) Baseline versus modified bias field; (b) Baseline versus modified bias field followed by noise filtering; (c) Baseline versus modified noise, and (d) Baseline versus modified noise followed bias field correction. The concordance correlation coefficient (CCC), dynamic range (DR), and interclass correlation coefficient (ICC) were used as metrics. Shape features and subsequently, local binary pattern (LBP) filtered images were highly stable and reproducible against bias field correction and noise filtering in all measurements. In all MRI modalities, necrosis regions (NC: n ̅ ~449/1461, 30%) had the highest number of highly robust features, with CCC and DR >= 0.9, in comparison with edema (ED: n ̅ ~296/1461, 20%), enhanced (EN: n ̅ ~ 281/1461, 19%) and active-tumor regions (TM: n ̅ ~254/1461, 17%). The necrosis regions (NC: n ¯  ~ 449/1461, 30%) had a higher number of highly robust features (CCC and DR >= 0.9) than edema (ED: n ¯  ~ 296/1461, 20%), enhanced (EN: n ¯  ~ 281/1461, 19%) and active-tumor (TM: n ¯  ~ 254/1461, 17%) regions across all modalities. Furthermore, our results identified t...

Source: Journal of Applied Clinical Medical Physics - December 26, 2019 Category: Physics Authors: Moradmand H, Aghamir SMR, Ghaderi R Tags: J Appl Clin Med Phys Source Type: research