Morindaquinone, a new bianthraquinone from Morinda coreia roots.

Morindaquinone, a new bianthraquinone from Morinda coreia roots.
Nat Prod Res. 2019 Dec 26;:1-7
Authors: Chokchaisiri S, Siriwattanasathien Y, Thongbamrer C, Suksamrarn A, Rukachaisirikul T
Abstract
Phytochemical investigation of the roots of Morinda coreia led to the isolation of one new bianthraquinone, morindaquinone (1), together with 12 known compounds, soranjidiol (2), rubiadin-1-methyl ether (3), 2-methoxy-1,3,6-trihydroxyanthraquinone (4), 1-hydroxy-2-methylanthraquinone (5), tectoquinone (6), nordamnacanthal (7), damnacanthal (8), 2-formylanthraquinone (9), 3-hydroxy-2-hydroxymethylanthraquinone (10), lucidin-ω-methyl ether (11), scopoletin (12) and (+)-mellein (13). The structures of these compounds were determined on the basis of extensive spectroscopic analyses, as well as by comparison with literature reports. Compound 1 was the first example of bianthraquinone found in the genus Morinda, whereas compound 13 was firstly isolated from this genus. Among them, compounds 2, 7, 8 and 10 exhibited moderate to weak cytotoxicity against human cervical (HeLa), human colon (HT 29) and human breast (MCF-7) cell lines, while compounds 6 and 9 - 11 showed weak anti-acetylcholinesterase activity.
PMID: 31876434 [PubMed - as supplied by publisher]

Source: Natural Product Research - December 25, 2019 Category: Biochemistry Authors: Chokchaisiri S, Siriwattanasathien Y, Thongbamrer C, Suksamrarn A, Rukachaisirikul T Tags: Nat Prod Res Source Type: research