Novel Series of Benzothiazole-Based Pyrazolidinediones Targeting PPAR γ. In Silico Studies, Synthesis and In Vivo Anti-Diabetic Activity.

CONCLUSION: Among the tested compounds, N-(6-chloro-5-methylbenzo[d]thiazol-2-yl-4-(4((3,5-dioxopyrazolidin-4-ylidene)methyl)phenoxy)butanamide 5b was found to be the most potent compound and provided valuable insights to further develop novel hybrids as anti-hyperglycemic agents. PMID: 31880249 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - Category: Chemistry Authors: Tags: Med Chem Source Type: research