Combining statin with antibiotic can 'increase risk of adverse events'

Combining the antibiotic clarithromycin with some statins increases the risk of adverse events, which may lead to hospital admission in older patients, according to Canadian researchers.
Source: Nursing Times Breaking News - Category: Nursing Source Type: news

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The objective of this hypothesis-generating post hoc subgroup analysis was to explore the effects of icosapent ethyl at 2 or 4 g/day (prescription pure ethyl ester of the omega-3 fatty acid eicosapentaenoic acid [EPA]) on atherogenic lipid, apolipoprotein, inflammatory parameters (high-sensitivity C-reactive protein [hsCRP], lipoprotein-associated phospholipase A2 [Lp-PLA2]), and oxidative parameters (oxidized-LDL [ox-LDL]) in statin-treated patients from ANCHOR with stage 3 CKD. Methods: The 12-week ANCHOR study evaluated icosapent ethyl in 702 statin-treated patients at increased CVD risk with triglycerides (TG) 200-499 ...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Publication date: June 2019Source: Chinese Medical Sciences Journal, Volume 34, Issue 2Author(s): Daowen Liu, Liqi Lei, Tong Ruan, Ping HeAbstractRegional healthcare platforms collect clinical data from hospitals in specific areas for the purpose of healthcare management. It is a common requirement to reuse the data for clinical research. However, we have to face challenges like the inconsistence of terminology in electronic health records (EHR) and the complexities in data quality and data formats in regional healthcare platform. In this paper, we propose methodology and process on constructing large scale cohorts which f...
Source: Chinese Medical Sciences Journal - Category: General Medicine Source Type: research
C-reactive protein (CRP) is a pentameric molecule made up of identical monomers. CRP can be seen in three different forms: native pentameric CRP (native CRP), non-native pentameric CRP (non-native CRP), and monomeric CRP (mCRP). Both native and non-native CRP execute ligand-recognition functions for host defense. The fate of any pentameric CRP after binding to a ligand is dissociation into ligand-bound mCRP. If ligand-bound mCRP is proinflammatory, like free mCRP has been shown to be in vitro, then mCRP along with the bound ligand must be cleared from the site of inflammation. Once pentameric CRP is bound to atherogenic lo...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractNo data exist whether statins have robust anti-inflammatory effects of atherosclerotic plaques primarily during the early treatment period or continuously throughout use. This prospective three time point18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) study of the carotid artery assessed anti-inflammatory effects of statin during the early treatment period (initiation to 3  months) and late treatment period (3 months to 1 year) and their correlation with lipid and inflammatory profile changes during a year of therapy. Nine statin-naïve stable angina patie...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
AbstractIntroductionDrug utilization and outcomes research in multi-ethnic Asian stroke populations is lacking.ObjectivesOur objective was to examine temporal trends and predictors of drug utilization and outcomes in a multi-ethnic Asian stroke population.MethodsThis registry-based study included ischemic and hemorrhagic first-ever stroke patients hospitalized between 2009 and 2016. Utilization of medications included in-hospital thrombolytic agents, early antithrombotics (antiplatelets, anticoagulants) within 48  h of admission, and antithrombotics and statins at discharge. Outcomes analyzed were in-hospital all-caus...
Source: CNS Drugs - Category: Neurology Source Type: research
(Elsevier) Statins, the most commonly used effective lipid-lowering drugs, are significantly underutilized to treat lipid abnormalities in patients with and at risk for atherosclerotic cardiovascular disease (ASCVD), according to a retrospective study of more than 280,000 patients in Alberta, Canada. Investigators report in the Canadian Journal of Cardiology that only two-thirds of these patients were receiving moderate/high-intensity statins, and of the ones treated, more than a third are under-treated.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
PMID: 31303605 [PubMed - as supplied by publisher]
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Study Design. Basic Science. Objective. To determine if locally delivered simvastatin can enhance bone formation in a rat spinal fusion model. Summary of Background Data. The bone-anabolic properties of statins in fracture healing are well established, however, few studies have evaluated the impact of locally delivered statins in spinal fusion. Methods. We formulated poly(lactic-co-glycolic acid) (PLGA) nanoparticles by adapting previously published techniques. Two types of nanoparticles were created: simvastatin nanoparticles (SimNP) and nanoparticles without simvastatin (BlankNP). Drug elution from SimNP was c...
Source: Spine - Category: Orthopaedics Tags: BASIC SCIENCE Source Type: research
Conclusions: Elevated baseline plasma interleukin-18 was associated with higher mortality in sepsis-induced acute respiratory distress syndrome. A rise in plasma interleukin-18 was also associated with increased mortality and was more common in subjects randomized to statin therapy in this clinical trial.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
ConclusionsSeveral existing and newer drug treatments reduce ASCVD risk through LDL cholesterol and/or triglyceride reduction in patients with diabetes. Novel approaches using antisense oligonucleotides and monoclonal antibodies may provide potential future therapies for diabetic dyslipidemia.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
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