Combining statin with antibiotic can 'increase risk of adverse events'

Combining the antibiotic clarithromycin with some statins increases the risk of adverse events, which may lead to hospital admission in older patients, according to Canadian researchers.
Source: Nursing Times Breaking News - Category: Nursing Source Type: news

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Beta-adrenergic blockers remain one of the cornerstones in the management of coronary artery disease, both in chronic stable angina and myocardial infarction. These recommendations were based on studies conducted in the era prior to the establishment of the modern therapy for ischemic heart disease and myocardial infarction i.e. anti-platelet therapy, statins, and percutaneous coronary interventions. Recent studies emerged questioning the beneficial effect of beta-blockers in the management of patients with stable ischemic heart disease and myocardial infarction. In this review, we will discuss briefly the pharmacology of ...
Source: Recent Patents on Cardiovascular Drug Discovery - Category: Cardiology Source Type: research
The objective of the study is t...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Conclusions: The present study detected a negative association between statin use and balance control in the ML direction, suggesting that caution should be taken when prescribing statins in older adults, as this could decrease ML stability and ultimately increase fall and fracture risks.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
AbstractAims/IntroductionWe evaluated the efficacy of multifactorial intensive treatment (IT) on renal outcomes in patients with type 2 diabetes and advanced stage of diabetic kidney disease (DKD).Materials and MethodsDiabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT ‐Japan) is a multi‐centered, open‐labeled, randomized controlled trial with a 5‐year follow‐up. We randomly assigned 164 patients with advanced stage of DKD (urinary albumin‐to‐creatinine ratio ≥300 mg/g creatinine, serum creatinine level: 1.2–2.5 mg/dl in male and 1.0–2.5 mg/dl in female) to receive either I...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: CLINICAL TRIAL Source Type: research
Low Density Lipoprotein Cholesterol (LDL-C) in children has been shown to predict development of atherosclerotic disease in adulthood.1 Statins are primarily used for lowering LDL-C exerting its effect through inhibition of hydroxymethylglutaryl coenzyme A reductase.2
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
CONCLUSION: European guidelines suggest general screening for risk factors, including analysis of lipid profiles in the population of 40-year-old males and 50-year-old or postmenopausal women. Our study documents high prevalence and incidence of CV risk factors together with insufficient control of the risk factors in Czech patients of this age range. This finding suggests that preventive examinations should be undertaken earlier (e.g., in 30-year-old males and 40-year-old women). Exact timing of the preventive check-ups to yield the best cost-benefit ratio needs to be verified. PMID: 32592555 [PubMed - as supplied by publisher]
Source: Central European Journal of Public Health - Category: International Medicine & Public Health Tags: Cent Eur J Public Health Source Type: research
In conclusion, metabolomics is a promising approach for the assessment of biological age and appears complementary to established epigenetic clocks. Sedentary Behavior Raises the Risk of Cancer Mortality https://www.fightaging.org/archives/2020/06/sedentary-behavior-raises-the-risk-of-cancer-mortality/ Living a sedentary lifestyle is known to be harmful to long term health, raising the risk of age-related disease and mortality. Researchers here show that a sedentary life specifically increases cancer mortality, and does so independently of other factors. This is one of many, many reasons to maintain a re...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, the results of the current study revealed that the statin rosuvastatin presents cardioprotective effects by activation of the JAK2/STAT3 signaling pathway. PMID: 32582964 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
CONCLUSIONS: Our findings suggest reduced neoatherosclerosis formation in magnesium-based BRS relative to DES. High dose statin treatment may be a promising measure to reduce neoatherosclerosis progression, both on its own and in synergy with site-targeted device-based treatment. PMID: 32583804 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
This study examined baseline characteristics of fee-for-service (FFS) Medicare beneficiaries newly initiating PCSK9i therapy during the period immediately following market availability.MethodsThis cross-sectional study used Medicare claims (2013 –2016) to identify 5051 FFS Medicare beneficiaries who filled ≥ 1 PCSK9i prescription between August 2015 and December 2016. We analyzed patient demographics, clinical characteristics, and baseline healthcare expenditures in the 12-month period prior to PCSK9i initiation, for these beneficiari es.ResultsMost beneficiaries initiating PCSK9i were female (57%),
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
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