A viewpoint on change point modeling for cognitive aging research: Moving from description to intervention and practice.
A viewpoint on change point modeling for cognitive aging research: Moving from description to intervention and practice. Ageing Res Rev. 2019 Dec 24;:101003 Authors: Sprague BN Abstract Chronological age is a commonly-used time metric, but there may be more relevant time measures in older adulthood. This paper reviews change point modeling, a type of analysis increasingly common in cognitive aging research but with limited application in applied research. Here, we propose a new application of such models for cognitive training studies. Change point models have the potential to assess intervention outcomes such as compression of morbidity or reduced decline after an event (e.g., reduced cognitive decline after a dementia diagnosis) as well as changes in outcome trajectories across different intervention dosages (e.g., initial vs. booster training). Through change point modeling, we can better understand how interventions impact cognitive aging trajectories. PMID: 31881367 [PubMed - as supplied by publisher]
Conditions: Dementia; Sleep Disorder; Mild Cognitive Impairment; Phototherapy Interventions: Device: Green LED light; Device: Red LED light (placebo) Sponsor: Kaohsiung Medical University Completed
Condition: Agitation in Patients With Dementia of the Alzheimer's Type Interventions: Drug: AVP-786; Drug: Placebo Sponsor: Avanir Pharmaceuticals Not yet recruiting
Condition: Frontotemporal Dementia Intervention: Biological: PR006 Sponsor: Prevail Therapeutics Not yet recruiting
The antidepressant bupropion was no better than placebo in reducing apathy in nondepressed patients with Alzheimer-type dementia in a randomized controlled trial.Medscape Medical News
Safeguarding adults with dementia is an important part of everyday work for providers of adult social care. This quick guide aims to support care providers and staff to safeguard people with dementia during the crisis. There are increased concerns that, during the COVID-19 crisis, people may be more vulnerable to abuse or neglect.
The intent of this trans-NIH initiative would be to invite research to determine the role and impact of digital health interventions (e.g., mobile health (mHealth), telemedicine and telehealth, health information technology, wearable devices) to address secondary health effects of the social, behavioral, and economic changes following the COVID-19 pandemic, particularly among populations who experience health disparities and other vulnerable populations (e.g., essential medical personnel, emergency responders, and frontline workers in essential businesses or services; people who are residents of chronic care facilities, co...
DiscussionIf PROMs are helpful in improving patient outcomes for depression even to a small extent, then they are likely to be good value for money, given their low cost. The benefits could be considerable, given that depression is common, disabling, and costly.Trial registrationISRCTN no: 17299295. Registered 1st October 2018.
ConclusionCollectively these findings highlight the utility of targeted MS approaches to quantify biomarkers associated with AD that could be used for monitoring disease progression, stratifying patients for clinical trials and measuring therapeutic response.
Conclusions: These results suggest that attention to specific depressive symptom profile can improve diagnostic sensitivity and can be used to provide more individualized patient care.
DEMENTIA is an umbrella term for a number of conditions characterised by a decline in cognitive abilities. Speech problems are one of the first casualties - here are eight warning signs to watch out for.