The Ototoxic Potential of Cobalt From Metal-on-Metal Hip Implants: Objective Auditory and Vestibular Outcome

Objectives: During the past decade, the initial popularity of metal-on-metal (MoM) hip implants has shown a progressive decline due to increasingly reported implant failure and revision surgeries. Local as well as systemic toxic side effects have been associated with excessive metal ion release from implants, in which cobalt (Co) plays an important role. The rare condition of systemic cobaltism seems to manifest as a clinical syndrome with cardiac, endocrine, and neurological symptoms, including hearing loss, tinnitus, and imbalance. In most cases described in the literature, revision surgery and the subsequent drop in blood Co level led to (partial) alleviation of the symptoms, suggesting a causal relationship with Co exposure. Moreover, the ototoxic potential of Co has recently been demonstrated in animal experiments. Since its ototoxic potential in humans is merely based on anecdotal case reports, the current study aimed to prospectively and objectively examine the auditory and vestibular function in patients implanted with a MoM hip prosthesis. Design: Twenty patients (15 males and 5 females, aged between 33 and 65 years) implanted with a primary MoM hip prosthesis were matched for age, gender, and noise exposure to 20 non-implanted control subjects. Each participant was subjected to an extensive auditory (conventional and high-frequency pure tone audiometry, transient evoked and distortion product otoacoustic emissions [TEOAEs and DPOAEs], auditory brainstem respons...
Source: Ear and Hearing - Category: Audiology Tags: Research Articles Source Type: research

Related Links:

Authors: Ontario Health (Quality) Abstract Background: Single-sided deafness refers to profound sensorineural hearing loss or non-functional hearing in one ear, with normal or near-normal hearing in the other ear. Its hallmark is the inability to localize sound and hear in noisy environments. Conductive hearing loss occurs when there is a mechanical problem with the conduction of sound vibrations. Mixed hearing loss is a combination of sensorineural and conductive hearing loss. Conductive and mixed hearing loss, which frequently affect both ears, create additional challenges in learning, employment, and quality of...
Source: Ontario Health Technology Assessment Series - Category: General Medicine Tags: Ont Health Technol Assess Ser Source Type: research
Conclusion: SCDS may be addressed surgically using multiple approaches. An underwater endoscopic repair of the SCC may be safe and effective surgical treatment. SDC video link: http://links.lww.com/MAO/A808.
Source: Otology and Neurotology - Category: ENT & OMF Tags: VIDEO REPORTS: PDF Only Source Type: research
Conclusions: The probability of seeking audiological evaluation for bothersome tinnitus is highest for males, middle-aged patients, and those with notched or high-frequency hearing losses. These findings support the theory that tinnitus arises from sharp discontinuities in peripheral afferent innervation and cochlear amplification, which may induce topographically restricted changes in the central auditory pathway.
Source: Otology and Neurotology - Category: ENT & OMF Tags: AUDIOLOGY Source Type: research
Internal jugular phlebectasia is a rare condition. Children with internal jugular phlebectasia are often discovered by their parents when they notice a soft mass in the neck that appears when the child cries, coughs, or breathes deeply. Most internal jugular vein dilatations occur unilaterally on the right side according to the literature reports. To our knowledge, no other internal jugular phlebectasia patients reported pulsatile tinnitus as the major complaint without a soft mass in the neck. The authors reported a female adult patient with left-side internal jugular phlebectasia with pulsatile tinnitus as the major comp...
Source: Journal of Craniofacial Surgery - Category: Surgery Tags: Brief Clinical Studies Source Type: research
Conditions:   Quality of Life;   Cancer;   Hearing Loss, Sensorineural;   Tinnitus, Subjective;   Late Effect Interventions:   Diagnostic Test: High frequency audiometry;   Other: Short-Form 36-Item Questionnaire (SF-36);   Other: Hearing handicap inventory for adults/elderly (HHIA/HHIE);   Other: Tinnitus handicap inventory (THI) Sponsors:   University of Nottingham;   National Institute for Health Research, United Kingdom;   International Stem Cell Forum Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article is a compilation of contributions that, together, make the case for an essential role of EHF in both normal hearing and auditory dysfunction. We start with the fundamentals of biological and acoustic determinism - humans have EHF hearing for a purpose, for example, the detection of prey, predators, and mates. EHF hearing may also provide a boost to speech perception in challenging conditions and its loss, conversely, might help explain difficulty with the same task. However, it could be that EHF are a marker for damage in the conventional frequency region that is more related to speech perception difficulties....
Source: Hearing Research - Category: Audiology Authors: Tags: Hear Res Source Type: research
Conditions:   Hearing Loss, Sensorineural;   Tinnitus, Subjective;   Cancer;   Chemotherapeutic Toxicity Intervention:   Diagnostic Test: High frequency pure tone audiometry Sponsors:   University of Nottingham;   National Institute for Health Research, United Kingdom;   International Stem Cell Forum Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Audiology | Audiometry | Brain | Cobalt | Neurology | Neurosurgery | Study | Tinnitus | Toxicology