Increased HLA-DR expression and cortical demyelination in MS links with HLA-DR15

Conclusions Our data indicate that increased HLA-DRB1 and -DRB5 expression in the brain of patients with MS may be an important factor in how the HLA-DR15 haplotype contributes to MS pathomechanisms in the target organ.

http://nn.neurology.org/cgi/content/short/7/2/e656?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - December 26, 2019 Category: Neurology Authors: Enz, L. S., Zeis, T., Schmid, D., Geier, F., van der Meer, F., Steiner, G., Certa, U., Binder, T. M. C., Stadelmann, C., Martin, R., Schaeren-Wiemers, N. Tags: Autoimmune diseases, Gene expression studies, Multiple sclerosis Article Source Type: research