Chromatin dynamics and histone modifications in the intestinal microbiota-host crosstalk

ConclusionsHost-microbiome interactions are important evolutionary drivers and are, thus, expected to be hardwired into and mould the epigenetic machinery in multicellular organisms. Microbial derived short chain fatty acids (SCFA) emerge as a dominant determinant in microbiome-host interaction and the inhibition of histone deacetylases (HDACs) by SCFA is a key mechanism in this process. The discovery of alternative histone acylations, such as crotonylation, in addition to the canonical histone acetylation reveals a new layer of complexity in this crosstalk.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research