Phyotochemical candidates repurposing for cancer therapy and their molecular mechanisms

Publication date: Available online 26 December 2019Source: Seminars in Cancer BiologyAuthor(s): Ji Hoon Jung, Jisung Hwang, Ju-Ha Kim, Deok Yong Shim, Eunji Im, Ji Eon Park, Woon Yi Park, Bum-Sang Shim, Bonglee Kim, Sung-Hoon KimAbstractThough limited success through chemotherapy, radiotherapy and surgery has been obtained for efficient cancer therapy for modern decades, cancers are still considered high burden to human health worldwide to date. Recently repurposing drugs are attractive with lower cost and shorter time compared to classical drug discovery, just as Metformin from Galega officinalis, originally approved for treating Type 2 diabetes by FDA, is globally valued at millions of US dollars for cancer therapy. As most previous reviews focused on FDA approved drugs and synthetic agents, current review discussed the anticancer potential of phytochemicals originally approved for treatment of cardiovascular diseases, diabetes, infectious diarrhea, depression and malaria with their molecular mechanisms and efficacies and suggested future research perspectives.
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research