Bioprinting a 3D vascular construct for engineering a vessel-on-a-chip.

In this study, we applied the gelatin-methacryloyl-based bioprinting technology to print 3D construct containing endothelial cells (ECs) and smooth muscle cells (SMCs) on a microfluidic chip. Compared with traditional culture system, EC-SMC coculturing chip model upregulated αSMA and SM22 protein expression of the SMC to a greater degree and maintains the contractile phenotype of the SMC, which mimics the natural vascular microenvironment. This strategy enabled us to establish an in vitro vascular model for studies of the physiologic and pathologic process in vascular wall.
PMID: 31875940 [PubMed - in process]

Source: Biomedical Microdevices - December 25, 2019 Category: Biomedical Engineering Authors: Abudupataer M, Chen N, Yan S, Alam F, Shi Y, Wang L, Lai H, Li J, Zhu K, Wang C Tags: Biomed Microdevices Source Type: research