Genetic alterations in thyroid tumours from patients irradiated in childhood for tinea capitis treatment.

Genetic alterations in thyroid tumours from patients irradiated in childhood for tinea capitis treatment. Eur J Endocrinol. 2013 Aug 21; Authors: Boaventura P, Pereira D, Celestino R, Mendes A, Nakasawa T, Teixeira-Gomes J, Sobrinho-Simoes M, Soares P Abstract OBJECTIVE - EXPOSURE TO IONIZING RADIATION AT YOUNG AGE IS THE STRONGEST RISK FACTOR FOR THE OCCURRENCE OF PAPILLARY THYROID CARCINOMA (PTC). RET/PTC REARRANGEMENTS ARE THE MOST FREQUENT GENETIC ALTERATIONS ASSOCIATED WITH RADIATION-INDUCED PTC, WHEREAS BRAF AND RAS MUTATIONS AND PAX8-PPARG REARRANGEMENT HAVE BEEN ASSOCIATED WITH SPORADIC PTC. WE DECIDED TO SEARCH FOR SUCH GENETIC ALTERATIONS IN PTCS OF PATIENTS SUBJECTED IN THE CHILDHOOD TO SCALP IRRADIATION.DESIGN - WE STUDIED 67 THYROID TUMOURS FROM 49 INDIVIDUALS IRRADIATED IN CHILDHOOD FOR TINEA CAPITIS SCALP EPILATION: 36 malignant (12 cases of conventional PTC - cPTC, 2 cPTC metastases, 20 cases of follicular variant PTC - FVPTC, one oncocytic variant of PTC and one follicular carcinoma) and 31 follicular adenomas (FTA).Methods - The lesions were screened for the BRAFV600E and NRAS mutations and for RET/PTC and PAX8-PPARG rearrangements.Results - BRAFV600E mutation was detected in 7 out of 14 (50%) cPTC and 2 out of 20 FVPTC (10%) (p=0.019). NRAS mutation was present in one case of FVPTC (5%). RET/PTC1 rearrangement was found, by RT-PCR, in one out of 17 cases (5.9%) and by FISH in 2 out of 6 cases (33%). PAX8-PPARG rearrangement was not detected...
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research

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Conclusions Vismodegib cannot replace complex reconstructions. However, in unresectable laBCC, Vismodegib can provide a bridge to surgery. Due to the possibility of persistent tumour cells, we recommend imaging-assisted surgery and an imaging-based follow-up. In case of complete clinical remission after Vismodegib in a neoadjuvant setting, we recommend that Vismodegib be continued as long as the adverse effects are tolerated and an imaging-based follow-up is advised. PMID: 31437079 [PubMed - as supplied by publisher]
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
This study aims to evaluate whether the McGill Thyroid Nodule Score (MTNS) accurately helps to decide the extent of surgery (hemithyroidectomy versus total thyroidectomy) based on the malignancy risk and to assess whether its use lowers the rate of completion thyroidectomy in cases of indeterminate thyroid nodules.MethodsWe performed a retrospective cohort study comparing MTNS results of patients undergoing hemithyroidectomy in King Abdulaziz Medical City, NGHA, Jeddah from the period of January 2013 to December 2017. We divided the cases into hemithyroidectomy who required completion and hemithyroidectomy who did not need...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Publication date: October 2019Source: Biomedicine &Pharmacotherapy, Volume 118Author(s): Ling Gao, Jian-zhong Sang, Hua CaoAbstractThe inhibitory effects of limonin have been disclosed in various tumors, however, its roles in nasopharyngeal carcinoma (NPC) progression are never been revealed. In the current work, we collected NPC cells with a higher stemness compared with bulk cells through isolating the side population (SP) cells. It was found that limonin exhibited a stronger inhibitory effect on SP cells than that in bulk cells, which was evident by a lower IC50 value. Additionally, limonin attenuated the stemness a...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Conclusions: Fibre-optic endoscope-guided 3D HDR ISBT boost could be an additional treatment strategy for locoregional residual NPC after radical EBRT, especially for deep invasive lesion. PMID: 31435431 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Conclusions: Cesium-131 interstitial brachytherapy is feasible and does not pose major radiation safety concerns; it should be considered as a treatment option for previously irradiated patients with recurrent, resectable HNC. PMID: 31435429 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Publication date: Available online 23 August 2019Source: Cancer GeneticsAuthor(s): Abdelkareem A. Ahmed, Mohammed Elmujtba Adam EssaAbstractThyroid cancer remains the highest prevailing endocrine malignancy, and its incidence rate has progressively increased in the previous years. Above 95% of thyroid tumor are follicular cells types of carcinoma in which are considered invasive type of tumor. The pathogenesis and molecular mechanism of thyroid tumors are yet remains elucidated, in spite of activating RET, RAS and BRAF carcinogenesis have been well introduced. Nemours molecular alterations have been defined and have reveal...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
Publication date: Available online 23 August 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Alexandra G. Pershina, Olga Ya. Brikunova, Alexander M. Demin, Oleg B. Shevelev, Ivan A. Razumov, Evgenii L. Zavjalov, Dina Malkeyeva, Elena Kiseleva, Nadezhda V. Krakhmal’, Sergey V. Vtorushin, Vasily L. Yarnykh, Vladimir V. Ivanov, Raisa I. Pleshko, Victor P. Krasnov, Ludmila M. OgorodovaAbstractNowadays there is growing recognition of the fact that biological systems have a greater impact on nanoparticle target delivery in tumors than nanoparticle design. Here we investigate the targeted delivery o...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
CONCLUSION: More than 50% of low-risk PTMC are on AS in Japan. However, the indication and recommendation for AS vary significantly between institutions. To improve the implementation of this management modality, physicians and patients should be further educated, and the socio-medical environment should be improved. PMID: 31441377 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Curcumin decreases epithelial‑mesenchymal transition by a Pirin‑dependent mechanism in cervical cancer cells. Oncol Rep. 2019 Aug 21;: Authors: Aedo-Aguilera V, Carrillo-Beltrán D, Calaf GM, Muñoz JP, Guerrero N, Osorio JC, Tapia JC, León O, Contreras HR, Aguayo F Abstract Curcumin is a natural antioxidant polyphenol, which decreases epithelial‑mesenchymal transition (EMT) and cell migration in cervical cancer cells. However, the mechanism by which such a decrease occurs is unclear. It is well established that cervical cancer can be caused by high‑risk human papillomav...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Michalek J, Brychtova S, Pink R, Dvorak Z Abstract Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. Several biological and molecular criteria have been established for making a prognosis of OSCC. One of the most important factors affecting the risk of tumor recurrence and overall prognosis is perineural invasion and bone invasion. Perineural invasion is defined as a tumor spreading and the ability of tumor cells to penetrate around or through the nerve tissue. Perineural invasion can cause the tumor to spread to distant areas from the primary tumor location. One possible explanation for ...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research
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