Approaching infinite affinity through engineering of peptide-protein interaction [Biochemistry]

Much of life’s complexity depends upon contacts between proteins with precise affinity and specificity. The successful application of engineered proteins often depends on high-stability binding to their target. In recent years, various approaches have enabled proteins to form irreversible covalent interactions with protein targets. However, the rate of such reactions...

Source: Proceedings of the National Academy of Sciences - December 25, 2019 Category: Science Authors: Anthony H. Keeble, Paula Turkki, Samuel Stokes, Irsyad N. A. Khairil Anuar, Rolle Rahikainen, Vesa P. Hytonen, Mark Howarth Tags: PNAS Plus Source Type: research