Reply to Pitt and Lee: Occupancies of Ca2+ in complexes of calmodulin with voltage-gated sodium channels [Biological Sciences]

In PNAS, we describe a crystal structure of Ca2+-loaded calmodulin (Ca2+/CaM) in complex with the C-terminal region (CT) of the voltage-gated sodium channel NaV1.5 (1). We contrasted our findings with those of Wang et al. (2) for the following reasons: The title and abstract had suggested a structure of Ca2+/CaM...

Source: Proceedings of the National Academy of Sciences - December 25, 2019 Category: Science Authors: Filip Van Petegem, Bernd R. Gardill Tags: Letters Source Type: research