Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor

Conclusions:
The present study suggests that AGE-RAGE-induced ROS generation stimulates the release of DPP-4 from ECs, which could in turn act on ECs directly via the interaction with M6P/IGF-IIR, further potentiating the deleterious effects of AGEs. The blockade by linagliptin of positive feedback loop between AGE-RAGE axis and DPP-4 might be a novel therapeutic target for vascular injury in diabetes.

Source: Cardiovascular Diabetology - August 28, 2013 Category: Cardiology Authors: Yuji IshibashiTakanori MatsuiSayaka MaedaYuichiro HigashimotoSho-ichi Yamagishi Source Type: research