High risk of gastrointestinal hemorrhage in patients with systemic sclerosis

Systemic sclerosis (SSc), a life-threatening autoimmune disease characterized by vasculopathy. Numerous SSc patients demonstrate gastrointestinal (GI) involvement but the delicate GI bleeding risk remains spar...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research

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Conditions:   Microstomia;   Systemic Sclerosis Intervention:   Other: orofacial exercise program Sponsor:   Cukurova University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Juvenile Idiopathic Arthritis Interventions:   Drug: Genakumab;   Drug: Placebo for this trial Sponsors:   GeneScience Pharmaceuticals Co., Ltd.;   Peking Union Medical College Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Colchicine is commonly used in the treatment of inflammatory diseases, but what do we know about the potential adverse events associated with its use?Arthritis Research &Therapy
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news
US president called Modi and threatened ‘retaliation’ if country kept full export banCoronavirus – latest updatesSee all our coronavirus coverageIndia has approved some exports ofhydroxychloroquine, an anti-malaria drug being touted as a possible coronavirus treatment, after apparent pressure from Donald Trump, who has been urging Americans to take it.The tablets are used to prevent and treat malaria, lupus and rheumatoid arthritis but over the past week the US president has been aggressively promoting the drug as a treatment for coronavirus, despite there being no conclusive medical evidence to prove its...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: India South and Central Asia World news US news Malaria Coronavirus outbreak Infectious diseases Medical research Science Source Type: news
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Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Letter to the editor Source Type: research
Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis is poorly understood and lacks effective therapies. We undertook quantitative analyses of T cell infiltrates in the skin of 35 untreated patients with early diffuse SSc and here show that CD4+ cytotoxic T cells and CD8+ T cells contribute prominently to these infiltrates. We also observed an accumulation of apoptotic cells in SSc tissues, suggesting that recurring cell death may contribute to tissue damage and remodeling in this fibrotic disease. HLA-DR–expressing endothelial cells were frequent targets of apoptosis in SSc, consistent with ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Fibroblasts are key effector cells in tissue remodeling. They remain persistently activated in fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although fibroblast activation may be initiated by external factors, prolonged activation can induce an “autonomous,” self-maintaining profibrotic phenotype in fibroblasts. Accumulating evidence suggests that epigenetic alterations play a central role in establishing this persistently activated pathologic phenotype of fibroblasts. We demonstrated that in fibrotic skin of patients with systemic sclerosis (SSc), a prototypical idiopathic fib...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Dynamic arterial elastance (Eadyn), the ratio between arterial pulse pressure and stroke volume changes during respiration, has been postulated as an index of the coupling between the left ventricle (LV) and the arterial system. We aimed to confirm this hypothesis using the gold-standard for defining LV contractility, afterload, and evaluating ventricular-arterial (VA) coupling and LV efficiency during different loading and contractile experimental conditions. Twelve Yorkshire healthy female pigs submitted to three consecutive stages with two opposite interventions each: changes in afterload (phenylephrine/nitroprusside), ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Tumor necrosis factor-α inhibitors (TNFis) have revolutionized the management of rheumatoid arthritis (RA), however despite considerable progress, only a small proportion of patients maintain long-term clinical response. Selection of, and switching between, biologics is mainly empirical, experiential, and not evidence-based. Most biopharmaceutical proteins (BP) can induce an immune response against the foreign protein component. Immunogenicity and the development of anti-drug antibodies (ADAs) is considered one of the main reasons for loss of therapeutic efficacy (secondary failure). ADAs may neutralize and/or promot...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
At midnight on Thursday March 26, all of South Africa went into lockdown. For the next 21 days, no one is to leave their homes unless they are going to the grocery store, the pharmacy or to seek medical help. No dog walking, no jogging, no food delivery services. Only essential workers are exempt, and that list is small. When President Cyril Ramaphosa made the announcement on March 23, a week after shutting the nation’s schools, there were only 402 confirmed COVID-19 cases. But it was essential, he said, to “flatten the curve” before widespread outbreaks overwhelmed the country’s fragile medical sys...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 feature Londontime Source Type: news
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