Antimicrobial Resistance Profile and Molecular Characteristics of Staphylococcus aureus Isolates from Hospitalized Adults in Three Regions of Vietnam.

This study aimed to investigate the antimicrobial resistance profile, multidrug resistance (MDR), and molecular characteristics of pathogenic Staphylococcus aureus isolates among hospitalized Vietnamese adults. Two-hundred twenty-three pathogenic S. aureus isolates were collected from hospitals in three regions of Vietnam. The minimum inhibitory concentrations were determined for antibiotic susceptibility of isolates. The molecular characteristics of S. aureus isolates were investigated using analysis of antibiotic-resistant genes, staphylococcal cassette chromosome mec typing, pulsed-field gel electrophoresis, and multilocus sequence typing. Substantial differences among three regions were found in the rates of methicillin-resistant S. aureus (north: 48.6%, central: 58.7%, south: 78.9%) and MDR (north: 65.8%, central: 79.7%, and south: 84.2%). The rates of genes tetK/M, aacA/aphD, ermA/B/C, and mecA increased substantially from north to south. ST188-SCCmecIV and ST239-SCCmecII isolates were most commonly found in the two largest clusters. The ST188 predominance was observed in the largest cluster in methicillin-resistant and methicillin-sensitive S. aureus isolates including SCCmecIII and SCCmecIVa in fatal cases. Our results revealed a high occurrence of MDR and a possible north-south trend in antibiotic resistance profile, MDR patterns, and rates of antibiotic-conferring genes among the S. aureus isolates. The ST188 predominance raises concerns about the globally important...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research