68Ga-DOTA-RGD2 PET/CT in radioiodine (131I) refractory thyroid cancer - Prospective comparison of diagnostic accuracy with 18F-FDG PET/CT and evaluation towards potential theranostics.

CONCLUSIONS: 68Ga-DOTA-RGD2 PET/CT showed a similar sensitivity to, but higher specificity and overall accuracy than 18F-FDG PET/CT in detection of lesions in RAIR-DTC patients. This novel application of the angiogenesis imaging modality can prove useful in RAIR-DTC, especially in patients with negative/ suspicious 18F-FDG PET/CT. Further, since majority of patients (82.1%) positive on 68Ga-DOTA-RGD2 PET/CT showed radiotracer avidity towards the higher end of the spectrum (grade IV and V), novel 177Lu-based theranostics can be a potential treatment for these patients. PMID: 31870227 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research