Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood.

CONCLUSIONS: Our findings show an association between PE-induced morphological activation of microglia and impaired DA neuron morphology in the VTA. Importantly, postnatal environmental intervention rescues possible PE-induced microglial activation. These data support that environmental intervention can be effective in ameliorating cognitive and behavioral deficits associated with VTA DA neuron dysfunctions, such as attention deficits and increased addiction risk. PMID: 31872887 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research

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The dangers of alcohol begin at the first sip of the first drink. Although most responsible drinking habits shouldn’t be cause for major concern, everyone who drinks runs the risk of encountering the negative effects of alcohol. The Dietary Guidelines for Americans defines moderate drinking as up to 1 drink per day for women and up to 2 drinks per day for men.  A single drink is considered as: 12 ounces of beer (5% alcohol content) 8 ounces of malt liquor (7% alcohol content) 5 ounces of wine (12% alcohol content) 1.5 ounces of 80-proof (40% alcohol content) distilled spirits or liquor (e.g., gin, rum, vodka, ...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism alcohol abuse alcohol dependence alcohol dependency alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility Alcoholics Anonymous Source Type: blogs
While recreational marijuana is legal in 11 states as of November 2019, more states gravitating toward legalizing the recreational use of the substance, and 33 states allowing medical marijuana, there’s apparently no stopping this trend. Cannabis, in the form of marijuana, hemp, and cannabidiol (CBD)  is being used for pain relief, to alleviate stress, cope with anxiety, and a number of other mental health disorders and addictions. Yet, there’s a dearth of clinical studies that have been conducted on the overall effects on a user’s health. Clearly, as Crain’s Detroit Business points out, more ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Medications Substance Abuse Cannabis Marijuana Source Type: blogs
“A crisis is a terrible thing to waste,” is a phrase coined by Stanford economist Paul Romer. Politicians are always in search of new crises to address—new fires to put out—with rapid and decisive action. In their passion to appear heroic to their constituents they often act in haste, not ta king the time to develop a deep and nuanced understanding of the issue at hand, insensitive to the notion that their actions might actually exacerbate the crisis.An example of that lack of understanding was made apparent in a  press release by the office of House Majority Whip Steve Scalise (R-LA) on J...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
One of every 13 women worldwide who consumed alcohol during pregnancy is estimated to have had a child with fetal alcohol spectrum disorder (FASD), according to astudy published today inJAMA Pediatrics. Based on these global estimates, some 630,000 infants with FASD are born each year.The analysis also revealed FASD is notably more frequent among aboriginal populations, children in foster care and residing in orphanages, incarcerated populations, and those in psychiatric care.“The higher prevalence emphasizes that these high-risk populations deserve special attention for the planning and organization of targeted scre...
Source: Psychiatr News - Category: Psychiatry Tags: alcohol children FASD fetal alcohol spectrum disorder JAMA Pediatrics Source Type: research
(Centre for Addiction and Mental Health) Globally, nearly eight out of every 1,000 children in the general population is estimated to have Fetal Alcohol Spectrum Disorder (FASD), according to a new study by the Centre for Addiction and Mental Health (CAMH). In addition, it's estimated that one out of 13 women who consumed any alcohol at any point or frequency during pregnancy delivered a child with FASD.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
SEX-SPECIFIC EFFECTS OF DEVELOPMENTAL ALCOHOL EXPOSURE ON COCAINE-INDUCED PLACE PREFERNCE IN ADULTHOOD. Behav Brain Res. 2017 Jun 06;: Authors: Macht VA, Kelly SJ, Gass JT Abstract Fetal Alcohol Syndrome (FAS) is associated with high rates of drug addiction in adulthood. One possible basis for increased drug use in this population is altered sensitivity to drug-associated contexts. This experiment utilized a rat model of FASD to examine behavioral and neural changes in the processing of drug cues in adulthood. Alcohol was given by intragastric intubation to pregnant rats throughout gestation and to ra...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
(Centre for Addiction and Mental Health) Worldwide, an estimated 119,000 children are born with fetal alcohol syndrome (FAS) each year, a new study from Canada's Centre for Addiction and Mental Health shows. The study, published in The Lancet Global Health, provides the first-ever estimates of the proportion of women who drink during pregnancy, as well as estimates of FAS by country, World Health Organization region and worldwide.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news
Publication date: Available online 13 January 2017 Source:The Lancet Global Health Author(s): Svetlana Popova, Shannon Lange, Charlotte Probst, Gerrit Gmel, Jürgen Rehm Background Alcohol use during pregnancy is the direct cause of fetal alcohol syndrome (FAS). We aimed to estimate the prevalence of alcohol use during pregnancy and FAS in the general population and, by linking these two indicators, estimate the number of pregnant women that consumed alcohol during pregnancy per one case of FAS. Methods We began by doing two independent comprehensive systematic literature searches using multiple electronic databases f...
Source: The Lancet Global Health - Category: Global & Universal Source Type: research
Introduction Fetal alcohol spectrum disorder (FASD) is a significant public health concern. To prevent FASD, factors that place women at risk for giving birth to children with FASD must be investigated; however, there are little data in this area. This paper describes the development of the Manitoba mothers and FASD study, a retrospective cohort of mothers whose children were diagnosed with FASD, generated to investigate: (1) risk factors associated with giving birth to children with FASD; (2) maternal physical and health outcomes, as well as the usage of health and social services. Methods The study population will be id...
Source: BMJ Open - Category: Journals (General) Authors: Tags: Open access, Addiction, Epidemiology Protocol Source Type: research
One of my challenges in working with patients suffering from addictive illnesses is to help increase their motivation to stick with a long-term recovery plan. This is a significant challenge for many reasons, especially because the disease of addiction affects the brain's ability to value long term recovery. The one exception to this difficulty, in many cases, is when a female patient gets pregnant. I have witnessed women who struggled for years with an addictive illness discover they are pregnant and, when the pregnancy is wanted, are able to make incredible strides in their recovery. They are often able to maintain sobri...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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