Isolation of tyrosine derived phenolics and their possible beneficial role in anti-inflammatory and antioxidant potential of Tithonia tubaeformis.

Isolation of tyrosine derived phenolics and their possible beneficial role in anti-inflammatory and antioxidant potential of Tithonia tubaeformis. Nat Prod Res. 2019 Dec 24;:1-9 Authors: Nawaz NUA, Saeed M, Khan KM, Ali I, Bhatti HA, Shahid M, Faizi S Abstract The methanolic extract of aerial parts of Tithonia tubaeformis showed significant antioxidant activity in DPPH assay. It was subjected to bioassay guided fractionation affording more active ethyl acetate fraction which on further purification led to the isolation and identification of a series of bioactive phenolic compounds having important biosynthetic relationship. Of these, 4-hydroxyphenethyl henicosanoate (tithonoid) is a new compound. Moreover, in the carrageenan induced paw edema test, significant attenuation of inflammation was also produced by the extract at 50-200 mg/kg. The structures of all the constituents were determined through spectroscopic methods. It is the first systematic biological and chemical investigation on T. tubaeformis, which showed that phenolics may play an important role in the antioxidant and anti-inflammatory activity of the plant, probably through synergism. PMID: 31872778 [PubMed - as supplied by publisher]
Source: Natural Product Research - Category: Biochemistry Authors: Tags: Nat Prod Res Source Type: research