Two new isoquinoline alkaloids from the seeds of Nandina domestica.

Two new isoquinoline alkaloids from the seeds of Nandina domestica.
Nat Prod Res. 2019 Dec 24;:1-7
Authors: Qin J, Zhang SY, Zhang YB, Chen LF, Chen NH, Wu ZN, Luo D, Wang GC, Li YL
Abstract
Two new isoquinoline alkaloids, 6 R,6aS-N-nantenine Nβ-oxide (1), 6S,6aS-N-nantenine Nα-oxide (2), along with nine known alkaloids, nantenine (3), oxonantenine (4), protopine (5), nornantenine (6), N-methyl-laurotetanine (7), isocorydine (8), O-methyflavinantine (9), N-methyl-2,3,6-trimethoxymorphinan-dien-7-one Nβ-oxide (10) and (+)-10-O-methylhernovine Nβ-oxide (11) were isolated from the seeds of Nandina domestica. Their structures were elucidated by extensive analyses of spectroscopic data (IR, UV, HRESIMS, 1 D and 2 D NMR), ECD calculation and comparison with the related literatures. In addition, the cytotoxicity against A549 cells of these alkaloids was determined by the MTT assay.
PMID: 31872787 [PubMed - as supplied by publisher]

Source: Natural Product Research - December 23, 2019 Category: Biochemistry Authors: Qin J, Zhang SY, Zhang YB, Chen LF, Chen NH, Wu ZN, Luo D, Wang GC, Li YL Tags: Nat Prod Res Source Type: research