A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides

Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Jie ZHANG, Chuan-Xi WANG, Xiao-Jun SONG, Shuang LI, Huan ZHAO, Guo-Dong CHEN, Dan HU, Hao GAO, Xin-Sheng YAOAbstractA pair of new tirucallane triterpenoid epimers, picraquassins M and N (1> and 2), were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their AChE inhibitory activity, cytotoxicity against five human tumour cell lines (SW480, MCF-7, HepG2, Hela, and PANC-1), and antimicrobial activity against two bacteria (Staphylococcus. aureus 209P and Escherichia coli ATCC0111) and two fungi (Candida albicans FIM709 and Aspergillus niger R330) were evaluated.
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research