Acquired Glanzmann Thrombasthenia Associated with Platelet Desialylation.

CONCLUSIONS: We report the first case of a patient with acquired GT due to ITP with FcγRIIa mediated platelet desialylation, independent of platelet activation. Treatment with neuraminidase inhibitor may prevent platelet clearance by anti-αIIb β3 antibodies. PMID: 31869497 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31869497?dopt=Abstract

Source: Thrombosis and Haemostasis - December 22, 2019 Category: Hematology Authors: Zheng SS, Perdomo JS, Leung HHL, Yan F, Chong BH Tags: J Thromb Haemost Source Type: research