Rerun: Happy 7th birthday to the Health Business Blog
The Health Business Blog is on vacation and re-running some classic posts. This one is from March 2012, the seventh birthday of the Health Business Blog. The Health Business Blog turns seven years old today. Continuing a tradition I established with birthdays one, two, three, four, five and six, I have picked out a favorite post from each month. Thanks for continuing to read the blog! March 2011: Why you shouldn’t feel good about paying a low price for wet AMD treatment Repackaging Avastin seems like a harmless, clever trick to save thousands on Lucentis. But now that the world has decided that the price point for a wet AMD treatment is $20 or so who is going to bother developing a new treatment for wet AMD? I’ve already seen situations where companies chose to drop development of early stage compounds in this therapeutic area because they are afraid they can’t make money. April 2011: Are decision support tools turning doctors into idiots? Some physicians are reluctant to used computerized decision support (CDS) tools because they fear loss of respect from patients and colleagues. I prefer physicians who uses sophisticated decision aids such as SimulConsult, which allows physicians to extend their expert knowledge to make differential diagnoses of rare conditions that even excellent, experienced specialists may see rarely in the course of a career. Point of care information tools such as UpToDate ...
Conclusion: Chinese women had a substantially lower risk of venous thromboembolism during pregnancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early pregnancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization. PMID: 31730677 [PubMed]
Conclusion: ARL is a heterogeneous disease. Histologic subtype is a major determinant of the clinical outcome. ADL has significantly lower CD4 counts than those of NADL. There is an urgent and unmet need for uniform management guidelines for improving outcomes in this under-represented patient population. PMID: 31730692 [PubMed]
CONCLUSIONS: Because of its pleiotropic roles in several reproductive events and its association with some life-threatening pathological conditions of pregnancy, bikunin may represent a non-invasive marker for improving follow-up and early diagnosis. Studies showing its usefulness as a drug for reducing the risk of preterm delivery and improving neonatal outcomes have yielded interesting results that deserve to be investigated through further research. PMID: 31728877 [PubMed - as supplied by publisher]
ConclusionsTaken together, these results illustrate a new model in which Purβ functions to regulate the glucagon/ADCY6/cAMP/PKA/CREB signaling pathway to help maintain glucose homeostasis.Graphical abstract
ConclusionsThe use of the tesaglitazar-[F7, P34]-NPY conjugate is a promising strategy to make use of the beneficial PPARα/γ effects in adipocytes while potentially omitting adverse-effects in other tissues.Graphical abstract
We describe the principal mechanisms of resistance to anti-VEGF therapy and discuss potential biomarkers to be investigated in the near future.
Conclusion: Here we discuss the major implications of these findings for the association between microorganisms and cancer, and also between some immune pathologies, like autoimmune diseases, and cancer.
A second phase 3 study has shown impressive reductions in LDL on top of statins with this novel agent given just twice a year.Medscape Medical News
In this study, silk nanofibrous scaffold (3D) was fabricated by electrospinning and then its biocompatibility and non-toxicity by MTT assay. After that, scaffold supportive effects on human induced pluripotent stem cells (hiPSCs) differentiation to insulin producing cells (IPCs) was studied at the gene and protein levels. IPCs related genes and proteins were up regulated in electrospun silk group significantly greater than tissue culture plates group (2D). In addition, another part of the results demonstrated that differentiated cells on 2D and 3D groups have great functional properties including C-peptide and insulin secr...
Publication date: Available online 15 November 2019Source: Neurochemistry InternationalAuthor(s): W. Zhong, N.A. DarmaniAbstractGlycogen synthase kinase 3 (GSK-3) is a constitutively active multifunctional serine-threonine kinase which is involved in diverse physiological processes. GSK-3 has been implicated in a wide range of diseases including neurodegeneration, inflammation, diabetes and cancer. GSK-3 is a downstream target for protein kinase B (Akt) which phosphorylates GSK-3 and suppresses its activity. Based upon our preliminary findings, we postulated Akt's involvement in emesis. The aim of this study was to investi...
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