Factors Associated with Knee Arthroplasty in a Knee Osteoarthritis Patient Cohort Treated with Intra-articular Injections of Hylan G-F 20
This study evaluated time to knee arthroplasty (KA), KA risk factors, and health care resource utilization in patients aged ≥18 years with claims in the Optum Clinformatics Data Mart database (2006–2016) for knee osteoarthritis treated with at least one course of hylan G-F 20. Kaplan–Meier analysis estimated KA risk from osteoarthritis diagnosis and first hylan G-F 20 treatment. KA risk factors were determined using multivariate Cox regression. Among 62,033 patients treated with hylan G-F 20 and/or hylan G-F 20 single intra-articular injection, 60 to 64% did not undergo KA 8 years following first injection. KA risk factors from time of osteoarthritis diagnosis and first hylan G-F 20 treatment were similar: increased age, fewer comorbidities, fewer hylan G-F 20 treatments, female sex, and no ultrasound/fluoroscopy for injection guidance. Patients who underwent KA versus those who did not had more office visits and claims for opioids, nonsteroidal anti-inflammatory drugs, and physical therapy. Patients less likely to undergo KA were younger (
WEDNESDAY, April 8, 2020 -- Folks with knee arthritis will get more out of physical therapy than a cortisone shot, a new clinical trial argues. People with osteoarthritis of the knee had less pain and disability after one year of physical therapy...
Conditions: Knee Pain; Chronic Osteoarthritis; Avascular Necrosis of the Femoral Condyle; Moderate Varus, Valgus or Flexion Deformities; Rheumatoid Arthritis Interventions: Procedure: Device: Persona Total Knee; Procedure: Device: NexGen Total Knee; Procedure: Device: Vanguard Total Knee Sponsor: Zimmer Biomet Not yet recruiting
Authors: Li F, Wu C, Sun H, Zhou Q Abstract AIMS: To study the effect of platelet-rich plasma (PRP) injections on pain reduction in patients with temporomandibular joint osteoarthritis (TMJ OA). METHODS: The authors performed a comprehensive search of the MEDLINE, PubMed, and Web of Science databases to retrieve RCTs published up to July 2018. Pain outcomes (visual analog scale scores) were extracted to assess the effect of PRP injections on TMJ OA. All data analyses were conducted using RevMan 5.3. RESULTS: Six studies were included. According to the results of these trials, intra-articular injections of P...
This study examines the relationship between quantitative sensory testing (QST) and clinical measures of pain sensitization in people with knee OA. Methods: A secondary analysis of data from 134 participants with knee OA was performed. Clinical measures included: manual tender point count (MTPC), the Central Sensitization Inventory (CSI) to capture centrally mediated comorbidities, number of painful sites on a body chart, and neuropathic pain-like symptoms assessed using the modified PainDetect Questionnaire. Relationships between clinical measures and QST measures of pressure pain thresholds (PPTs), temporal summation,...
CONCLUSIONS: Compared to placebo, there was a beneficial effect of PEMF therapy on pain, stiffness, and physical function in patients with OA. Duration of treatment may not be a critical factor in pain management. Further studies are required to confirm effects of PEMF therapy on QOL. IMPACT STATEMENT: Our study suggests that PEMF therapy has clinically significant effects on pain in patients with OA. The current evidence was limited to the short-term effects of PEMF therapy. PMID: 32251502 [PubMed - as supplied by publisher]
In this study, we aimed to investigate effective therapies to reverse or suppress TMJOA progression.
ConclusionsIn our opinion, first COMP increasing can be caused by injection of platelet rich plasma. It is not adequate to interpret this growth in COMP levels as increased osteochondral degeneration. One year follow-up period showed good quality of life improvement, significant pain reduction, and essential MRI changes. The long-term observation of these cohort of patients combined with an analysis of MRI images is still ongoing.
Condition: Patellofemoral Osteoarthritis Interventions: Device: Elastic hip strap; Device: Insole Sponsors: Universidade Federal de Sao Carlos; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Not yet recruiting
ConclusionIn patients with symptomatic knee OA, the presence of knee CC did not affect the risk of arthroplasty or disease progression at 5 years.
Conditions: Osteo Arthritis Knee; Pain, Chronic; Pain Intervention: Other: Dry cupping therapy Sponsor: Universidade Federal do Rio Grande do Norte Not yet recruiting