Somatic PRKAR1A mutation in sporadic atrial myxoma with cerebral parenchymal metastases: a case report

ConclusionsOur patient illustrates that mutations inPRKAR1A may be found in sporadic lesions. Whether the presence of this mutation affects the clinical behavior of sporadic tumors and increases risk for metastasis is not clear. Regardless, the protein kinase A pathway which is regulated byPRKAR1A represents a possible target for treatment in patients with metastatic cardiac myxomas harboring mutations in thePRKARIA gene.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research