T-Cell Reconstitution after Lymphocyte Depletion Features a Different Pattern of Inhibitory Receptor Expression in ABO- Versus HLA-Incompatible Kidney Transplant Recipients.

T-Cell Reconstitution after Lymphocyte Depletion Features a Different Pattern of Inhibitory Receptor Expression in ABO- Versus HLA-Incompatible Kidney Transplant Recipients. Clin Exp Immunol. 2019 Dec 23;: Authors: Del Bello A, Kamar N, Treiner E Abstract Chronic antigen stimulation can lead to immune exhaustion (a state of T cell dysfunction). Several phenotypic signatures of T cell exhaustion have been described in various pathological situations, characterized by aberrant expression of multiple inhibitory receptors (IR). This signature has been barely studied in the context of allogenic organ transplantation. We undertook a cross-sectional analysis of the expression of IR (CD244, CD279, TIGIT and CD57) and their correlation with cytokine-producing functions in T cells reconstituting after lymphocyte depletion in patients transplanted from living donors, with preformed donor-specific antibodies. After ABO incompatible transplantation, T cells progressively acquired a phenotype similar to healthy donors, and the expression of several IR marked cells with increased functions, with the exception of TIGIT, which was associated with decreased cytokine production. In stark contrast, T cell reconstitution in patients with anti-HLA antibodies was characterized with an increased co-expression of IR by T cells, and specifically by an increased expression of TIGIT. Furthermore, expression of these receptors was no longer directly correlated t...
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research