Tranexamic acid in gynecologic surgery.

Tranexamic acid in gynecologic surgery. Curr Med Res Opin. 2019 Dec 21;:1 Authors: Zakhari A, Sanders AP, Solnik MJ Abstract Objective: To review the mechanism of action, pharmacology, dosing, and complications of tranexamic acid (TXA) and consolidate current evidence for TXA in gynecologic surgery.Methods: A literature search of PubMed, Ovid (MEDLINE), Google Scholar, and Elsevier was performed, in addition to a targeted search of cited references involving TXA and gynecologic surgery. Preference was given to systematic reviews and randomized control trials (RCTs).Results: TXA reversibly binds to plasminogen, preventing clot degradation. RCTs on hysterectomy, myomectomy, cervical conisation, hysteroscopy, and surgery for cervical and ovarian cancer were identified, as were case reports on TXA use for ectopic pregnancy. During hysterectomy, TXA reduces blood loss (two RCTs, n = 432, mean difference -66.0mL and 180mL), blood transfusion (1 RCT, n = 100, 12% versus 42%, p 
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research

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Abstract Gynecologic malignancies are common among cancers diagnosed during pregnancy, especially those of cervical and ovarian origin. Imaging is an important part of the diagnosis, staging, and follow-up of pregnancy-associated gynecologic tumors, with sonography and magnetic resonance (MR) imaging being the most suitable modalities. MR imaging is particularly useful in cervical cancer for the evaluation of tumor size, nodal, and extrapelvic disease. Ovarian tumor is initially diagnosed with sonography; MR imaging should be performed in cases of indeterminate ultrasonography findings and for staging. Pregnancy-r...
Source: Radiologic Clinics of North America - Category: Radiology Authors: Tags: Radiol Clin North Am Source Type: research
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Source: OnMedica Latest News - Category: UK Health Source Type: news
Gynecologic malignancies are common among cancers diagnosed during pregnancy, especially those of cervical and ovarian origin. Imaging is an important part of the diagnosis, staging, and follow-up of pregnancy-associated gynecologic tumors, with sonography and magnetic resonance (MR) imaging being the most suitable modalities. MR imaging is particularly useful in cervical cancer for the evaluation of tumor size, nodal, and extrapelvic disease. Ovarian tumor is initially diagnosed with sonography; MR imaging should be performed in cases of indeterminate ultrasonography findings and for staging. Pregnancy-related changes may...
Source: Radiologic Clinics of North America - Category: Radiology Authors: Source Type: research
Gynecologic malignancies are common among cancers diagnosed during pregnancy, especially those of cervical and ovarian origin. Imaging is an important part of the diagnosis, staging, and follow-up of pregnancy-associated gynecologic tumors, with sonography and magnetic resonance (MR) imaging being the most suitable modalities. MR imaging is particularly useful in cervical cancer for the evaluation of tumor size, nodal, and extrapelvic disease. Ovarian tumor is initially diagnosed with sonography; MR imaging should be performed in cases of indeterminate ultrasonography findings and for staging. Pregnancy-related changes may...
Source: Radiologic Clinics of North America - Category: Radiology Authors: Source Type: research
Conclusions: A close collaboration between Cancer and Fertility Center in a tertiary care hospital is essential to provide a good health service in oncological patients. Offering fertility preservation is no longer considered optional and must be included in every therapeutic program for women who receive an oncological diagnosis in their reproductive age. Oocyte cryopreservation is a good option for fertility preservation for women facing cancer treatment and our results, despite on a small sample, are encouraging. We also confirm a low utilization rate as only 4.5% of patients returned to use their gametes.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
This article reviews the research progress on the diagnosis and treatment principles of cervical cancer in pregnancy, in order to strike a balance between effective treatment of tumors and protection of fetal health, and avoid delays in treatment and preterm delivery.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: REVIEW Source Type: research
Alabama Gov. Kay Ivey on May 15 signed into law the strictest abortion ban in the country, sparking fears not only about abortion access, but also about how the policy could worsen disparities that already endanger the health of women living in the south. The law, set to become enforceable in six months, bans nearly all abortions at all stages of pregnancy, with exceptions only for serious threats to the mother’s health. It also makes performing abortions a crime for doctors, who could be convicted of a felony and face up to 99 years in prison. Until the law is enforced, abortion is still legally available in Alabama...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized abortion Abortion Ban medicine politics public health Source Type: news
Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neurons Hironori Bando1,2, Youngae Lee1,2, Naoya Sakaguchi1, Ariel Pradipta1, Ryoma Sakamoto1, Shun Tanaka1, Ji Su Ma1,2, Miwa Sasai1,2 and Masahiro Yamamoto1,2* 1Department of Immunoparasitology, Research Institute for Microbial Diseases, Suita, Japan 2Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan Toxoplasma gondii is an important human and animal pathogen that causes life-threatening toxoplasmosis. The host immune system produces interferon-γ (I...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Li Liu, Jiajing Lin and Hongying He* Department of Obstetrics and Gynecology, Liuzhou Worker’s Hospital, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China Background and Objective: Endometrial cancer (EC) is a common gynecological malignancy worldwide. Despite advances in the development of strategies for treating EC, prognosis of the disease remains unsatisfactory, especially for advanced EC. The aim of this study was to identify novel genes that can be used as potential biomarkers for identifying the prognosis of EC and to construct a novel risk stratification using these genes. Me...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In this study, vaginal microbiome was divided in five biotypes, being four of them dominated by lactobacilli and considered as healthy (pH 5.0) and higher diversity. In a healthy status, microbiota is balanced and forms a stable ecological unit dominated by Lactobacillus species, which fixes pH below 5.0 and controls non-desirable groups. In a pathogenic process, the microbiome shifts to a dysbiotic state, in which lactobacilli drop, pH is increased to values above 4.5 and other groups such as Gardnerella, Atopobium, Prevotella, and Streptococcus, among others, can overgrow (Srinivasan et al., 2012). Short chain fatty acid...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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