24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes -- a cross-sectional study

Background: Non-invasive measurements of 24 h ambulatory central aortic systolic pressure (24 h-CASP) and central pulse pressure (24 h-CPP) are now feasible. We evaluate the relationship between 24 h central blood pressure and diabetes-related complications in patients with type 1 diabetes. Methods: The study was cross-sectional, including 715 subjects: 86 controls (C), 69 patients with short diabetes duration (< 10 years), normoalbuminuria (< 30 mg/24 h) without receiving antihypertensive treatment (SN), 211 with longstanding diabetes (>= 10 years) and normoalbuminuria (LN), 163 with microalbuminuria (30-300 mg/24 h) (Mi) and 186 with macroalbuminuria (> 300 mg/24 h) (Ma).24 h-CASP and 24 h-CPP was measured using a tonometric wrist-watch-like device (BPro, HealthStats, Singapore) and derived using N-point moving average. Results: In C, SN, LN, Mi and Ma mean +/- SD 24 h-CASP was: 114 +/- 17, 115 +/- 13, 121 +/- 13, 119 +/- 16 and 121 +/- 13 mmHg (p < 0.001); and 24 h-CPP: 38 +/- 8, 38 +/- 7, 44 +/- 10, 46 +/- 11 and 46 +/- 11 mmHg, (p < 0.001).Following rigorous adjustment (24 h-mean arterial pressure and conventional risk factors), 24 h-CASP and 24 h-CPP increased with diabetes, albuminuria degree, previous cardiovascular disease (CVD), retinopathy and autonomic dysfunction (p
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research