Neoadjuvant chemotherapy and penile conservation in the management of Buschke – Lowenstein tumor, a case report

We present a case of BLT that was managed with neoadjuvant chemotherapy followed by phallic sparing surgery.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research

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Purpose of review To review the latest in penile cancer treatment focusing on neoadjuvant chemotherapy in patients with regional lymph node involvement. Recent findings Patients with regional lymph node involvement from penile cancer still suffer from a poor prognosis, and the chances to achieve cure are primarily dependent on the extent of the disease. Despite multiple lines of research are indicating the need for a multimodal management of the disease upfront, the search for newer effective systemic therapies is ongoing. The available guidelines currently suggest the use of combination chemotherapy regimens includin...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: PENIS CANCER: Edited by Oscar R. Brouwer and Daher C. Chade Source Type: research
ConclusionsIn this study, we found a very low rate of adherence to the EAU guidelines on systemic treatment for PeCa. Further investigations are needed to clarify whether this missing adherence is a consequence of limited individual knowledge level or of the low grade of guideline recommendations.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Chemotherapy may be a valuable treatment option as neoadjuvant treatment for locally advanced penile cancer according to some previous studies, but the rarity of the sample and the Lack of large-scale clinical...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Publication date: Available online 9 November 2018Source: Urology Case ReportsAuthor(s): Aeen M. Asghar, Andrew G. McIntosh, Alexander Kutikov, David YT. Chen, Daniel M. Geynisman
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
OW Abstract Over the past few decades, some principles in the treatment of penile cancer have changed fundamentally. While 15 years ago a negative surgical margin of at least 2 cm was considered mandatory, organ-sparing surgery permitting minimal negative surgical margins has a high priority nowadays. The current treatment principle requires as much organ preservation as possible and as much radicality as necessary. The implementation of organ-sparing and reconstructive surgical techniques has improved the quality of life of surviving patients. However, oncological and functional outcomes are still unsatisfacto...
Source: Aktuelle Urologie - Category: Urology & Nephrology Authors: Tags: Aktuelle Urol Source Type: research
AbstractOf 32 patients with penile cancer who underwent medical treatment in our institute between 1999 and 2016, 4 with locally advanced penile cancer received penectomy, neoadjuvant chemotherapy, and lymphadenectomy for regional lymph node metastases. The median age and follow-up period were 46 years and 79 months. Clinical lymph node (N) stages cN1, cN2, and cN3 were observed in 1, 2, and 1 patient, respectively. Except for 1 patient who had partial penectomy, all received total penectomy for the primary tumors. All pathological findings were squamous cell carcinoma. Among the specimens at the time of the primary tumors...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
Patients with locally inoperable primary tumors or advanced regional or distant metastatic penile cancer continue to represent a therapeutic dilemma.1 Neoadjuvant chemotherapy with subsequent surgical consolidation among responding patients can result in long-term survival in a subset. However, 40% to 50% of such patients do not respond and novel therapeutic strategies are required.2
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Adult Urology Source Type: research
Purpose of review: As penile cancer is an uncommon malignancy in the Western society, randomized trials to address the controversies in management have not previously been undertaken. The incorporation of multidisciplinary approaches in the management of advanced penile carcinoma has largely borrowed evidence from analogous malignancies in the anogenital region. This review is being undertaken in preparation for the international launch of InPACT, the International Penile Advanced Cancer Trial, a collaborative effort from European and North American trialists. Recent findings: The literature supporting the development of ...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: RARE UROLOGIC TUMORS: Edited by Axel S. Merseburger and Yair Lotan Source Type: research
A multimodal approach to therapy is increasingly used in treating men with advanced penile cancer. Adjuvant chemotherapy improves outcomes in chemotherapy-na ïve men with node-positive positive disease, and neoadjuvant chemotherapy can downstage bulky nodal disease sufficiently to permit surgery and has the potential to offer durable long-term survival. However, there remain several unanswered questions in this field, and international collaboration in the form of clinical trials is required to optimize treatment and improve survival in men with advanced penile cancer.
Source: Urologic Clinics of North America - Category: Urology & Nephrology Authors: Source Type: research
Conclusions Men with PC and pelvic node metastases may benefit from a bilateral PLND. This hypothesis requires further confirmation.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
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