Study of Drug Exposure in Systemic Circulation of Primatene Mist by Oral Inhalation, Versus Epinephrine Injection by Intramuscular Injection and ProAir by Oral Inhalation in Healthy Individuals

Conditions:   Pharmacokinetics;   Epinephrine;   Albuterol;   Asthma;   Anaphylaxis Interventions:   Combination Product: Epinephrine (0.125 mg/inhalation);   Combination Product: Epinephrine Injection Auto-Injector (0.3mg/0.3mL);   Combination Product: Albuterol Sulfate (0.09 mg/inhalation) Sponsor:   Amphastar Pharmaceuticals, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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We have read with interest the report by Dribin et al investigating the association between history of asthma and anaphylaxis severity in children 1. The authors concluded that children hospitalized for anaphylaxis with a past medical history of asthma were not more likely to have severe anaphylactic reactions compared with children without asthma. However, we noticed that asthma control status at the time of anaphylaxis was not determined in the study. As mentioned by the authors, a position paper from the European Academy of Allergy and Clinical Immunology identifies asthma as a risk factor for fatal anaphylaxis, but it ...
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Letters to the Editor Source Type: research
The objective of the study was to determine the extent to which patients with asthma adhere to a schedule of recommended vaccinations in Poland. Two hundred fourteen patients were recruited from specialist outpatient clinics in Warsaw to complete voluntarily an anonymous questionnaire created for the purpose of this study. Within the past year, 82% stated having at least one respiratory infection, and 72% of patients were aware of the recommendation for annual vaccination against the flu. Forty-three percent of patients reported receiving the flu vaccine at least once, and only 20% followed through with annual vaccination....
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
CONCLUSIONS: Selective EP2 agonism is a powerful pharmacological strategy to prevent MCs from being activated through IgE-mediated mechanisms and from causing deleterious effects. The MC EP2 receptor may be an effective pharmacological target in allergic and other MC-mediated conditions. PMID: 32400135 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
CONCLUSIONS: Lcr35 treatment during OIT had some synergic effect for protection against anaphylaxis in a mice model of egg allergy. These findings should be confirmed in future animal studies including more detailed immunological profiles and human studies. PMID: 32400134 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
ConclusionA multidisciplinary approach to the treatment of sinonasal symptoms using both escalation of medical therapy and surgical approaches may improve QOL of patients with suspected MCAS. Consensus criteria for MCAS, which includes elevation in tryptase over baseline during an episode, may exclude the full spectrum of individuals with MCAS from potentially beneficial treatment.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionOur data confirm the lack of consensus regarding the number of AAIs to prescribe. Despite the European Medical Agency recommendation, the majority of allergy experts prescribed one autoinjector per patient. However, under distinct circumstances (e.g. mastocytosis, asthma, excess body weight, a history of severe anaphylaxis, or restricted access to immediate emergency), experts tended to prescribe more AAIs, which is in accordance with the European Academy of Allergy and Clinical Immunology guidelines.
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
Purpose of review To present an update on the recent advances in the understanding of the mechanisms and practical management of oral mite anaphylaxis (OMA, pancake syndrome). Recent findings Among novel observations regarding OMA, this review highlights the increased prevalence of aspirin/NSAID hypersensitivity inpatients affected by OMA, the association of OMA with exercise-induced anaphylaxis, the presentation of OMA simulating acute asthma, the occurrence of OMA in childhood, the high severity and lethal potential of OMA, the contamination of other foods, such as oat and corn flour with mites, and the simultaneous...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: PERSONALIZED MEDICINE: Edited by Henry Milgrom and René Maximiliano Gómez Source Type: research
Conditions:   Asthma in Children;   Allergy Intervention:   Device: Advanced multimodal wireless vital signs monitor Sponsors:   Northwestern University;   Ann&Robert H Lurie Children's Hospital of Chicago Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
When a child presents to the emergency department (ED) with anaphylaxis the first priority is immediate stabilization. Shortly thereafter, though, the clinician must decide whether a prolonged period of monitoring, including hospitalization, is warranted. And although concomitant asthma is a recognized risk factor for severe anaphylaxis (Allergy 2014;69:1026-45), it may not be a strong predictor (Allergy 2016;71:1241-55) and little is certain as to whether a co-existing diagnosis of asthma should, in and of itself, enter into that decision to admit.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
Changing the immune responses to allergens is the cornerstone of allergen immunotherapy. Allergen-specific immunotherapy that consists of repeated administration of increasing doses of allergen extract is potentially curative. The major inconveniences of allergen-specific immunotherapy include failure to modify immune responses, long-term treatment leading to non-compliance and the potential for developing life-threating anaphylaxis. Here we investigated the effect of a novel liposomal formulation carrying low dose of allergen combined with CpG-ODN, a synthetic TLR9 agonist, on established allergic lung inflammation. We fo...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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